In the intricate world of organic synthesis, specific molecular building blocks are crucial for constructing complex chemical structures that underpin advancements in various fields, most notably pharmaceuticals. 2-Chloro-5-iodopyridine, identified by its CAS number 69045-79-0, is one such indispensable intermediate. Its unique halogen substitution pattern renders it highly reactive, making it a favored component for chemists engaged in drug discovery and the development of new synthetic methodologies.

Understanding the Reactivity: A Chemist's Perspective

The value of 2-Chloro-5-iodopyridine lies primarily in its dual halogen functionality. The iodine atom, being a relatively good leaving group, makes the molecule an excellent substrate for a wide array of metal-catalyzed cross-coupling reactions. These reactions, including palladium-catalyzed transformations like Suzuki, Heck, and Sonogashira couplings, are cornerstone techniques for forming new carbon-carbon bonds. This capability allows chemists to precisely assemble complex molecular architectures, which is fundamental for creating novel drug candidates. When you need to buy this intermediate, ensuring high purity from a reliable supplier is key to achieving efficient and selective coupling.

Applications in Pharmaceutical R&D

The application spectrum of 2-Chloro-5-iodopyridine is broad, but its role in pharmaceutical research is particularly significant. It acts as a pivotal intermediate in the multi-step synthesis of biologically active compounds. For example, it has been employed in the creation of inhibitors for enzymes like phosphodiesterase type 5 (PDE-V) and prostaglandin E synthetase (PGES-1), which are targets for various therapeutic interventions. Furthermore, research indicates its use in synthesizing anti-cancer agents, highlighting its importance in oncology drug development. Pharmaceutical companies and research institutions often seek this compound to accelerate their R&D pipelines, looking for dependable manufacturers who can supply it consistently.

Sourcing Considerations: Price and Availability from China

For procurement professionals and R&D scientists, understanding the market for 2-Chloro-5-iodopyridine is essential. Sourcing from a leading China manufacturer offers distinct advantages, including competitive pricing and readily available bulk quantities. Establishing a relationship with a reputable supplier ensures not only cost-effectiveness but also a stable supply chain, which is critical for uninterrupted research and production. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing this vital organic synthesis intermediate with the quality and reliability that the pharmaceutical industry demands. We encourage inquiries for quotations and samples to explore how we can support your synthesis needs.

The strategic utilization of 2-Chloro-5-iodopyridine empowers chemists to push the boundaries of molecular design. By partnering with a trusted supplier, you can ensure that your projects benefit from this versatile and essential chemical intermediate.