For professionals in the chemical and pharmaceutical industries, understanding the detailed specifications and proper handling procedures for key intermediates is crucial for safe and efficient operations. 4-Chloro-N-methylpyridine-2-carboxamide (CAS 220000-87-3) is a widely used intermediate, particularly in the synthesis of pharmaceuticals such as Sorafenib. This article outlines the essential specifications and best practices for its industrial use, providing valuable insights for procurement managers and production scientists.

The quality of chemical intermediates directly impacts the success of synthesis processes and the integrity of the final product. For 4-Chloro-N-methylpyridine-2-carboxamide, key specifications typically include: Purity, usually measured by High-Performance Liquid Chromatography (HPLC), often required to be ≥98.0% or higher. Appearance is commonly described as an off-white to pale yellow crystalline powder. Other important parameters that might be specified include loss on drying (typically ≤1.0%), residue on ignition, and limits for specific impurities. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. provide these detailed specifications to ensure product reliability.

When procuring 4-Chloro-N-methylpyridine-2-carboxamide, it is essential to obtain a comprehensive Certificate of Analysis (CoA) with each batch. This document verifies that the material meets the agreed-upon specifications. Safety Data Sheets (SDS) are also critical, providing detailed information on the chemical's hazards, safe handling, storage, and emergency procedures. These documents are vital for compliance and for ensuring a safe working environment.

Proper storage is key to maintaining the quality of 4-Chloro-N-methylpyridine-2-carboxamide. It should typically be stored in tightly sealed containers in a cool, dry, and well-ventilated place, protected from light and moisture. Following these guidelines helps prevent degradation and ensures the material remains suitable for use in sensitive pharmaceutical synthesis. For bulk purchases, understanding packaging options, such as 25 kg drums, and ensuring proper labeling is also important.

For industrial users looking to buy 4-Chloro-N-methylpyridine-2-carboxamide, partnering with a reputable manufacturer that emphasizes quality control and provides thorough documentation is a strategic decision. A reliable supplier not only offers high-purity materials but also supports your operations with essential technical information and a consistent supply chain. By adhering to these specifications and handling guidelines, you can effectively integrate this intermediate into your manufacturing processes, ensuring the production of high-quality pharmaceutical products.