For researchers and chemists in the laboratory, having access to detailed information on key chemical compounds is vital for successful experimentation and product development. (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol, identified by its CAS number 225920-05-8, is a prime example of such a compound, frequently sought after as a pharmaceutical intermediate. This article provides a focused look at its core specifications and critical applications, offering valuable insights for R&D professionals looking to buy this specialized chemical.

The chemical profile of (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol is characterized by its unique structure featuring two trifluoromethyl groups on a phenyl ring, attached to a chiral ethanol moiety. Its typical appearance is a white solid, with a reported melting point range between 53.0 to 57.0 °C. This specific chiral configuration and the presence of fluorine atoms are key to its reactivity and utility in complex synthesis. Purity levels, often specified as 95% minimum, are critical for ensuring reproducible results in sensitive research applications.

The primary application driving demand for (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol is its role as a crucial intermediate in the synthesis of Aprepitant. Aprepitant is a selective neurokinin-1 (NK1) receptor antagonist, widely used for the prevention of chemotherapy-induced nausea and vomiting. The precise stereochemistry of (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol is essential for the efficacy of the final drug product, underscoring the importance of sourcing high-enantiomeric purity material.

Beyond its use in Aprepitant production, this fluorinated chiral alcohol serves as a valuable building block in broader organic synthesis and medicinal chemistry research. Its structure can be further modified to create a diverse range of novel compounds with potential therapeutic applications. Researchers often seek suppliers that can guarantee consistent batch-to-batch quality and provide comprehensive technical data to support their experimental designs. When you need to buy this compound, understanding its specifications is key to selecting the right supplier.

For R&D scientists, sourcing from established chemical suppliers, particularly those with manufacturing capabilities in China, offers numerous advantages. These include competitive pricing for laboratory quantities, ready availability, and detailed product information necessary for rigorous scientific work. Engaging with a supplier that understands the demands of research and development ensures that you receive material suitable for your specific needs, whether for small-scale synthesis or pilot studies.

In essence, (1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethanol is a highly specialized chemical intermediate with critical applications in pharmaceutical synthesis. Understanding its specifications—appearance, melting point, purity, and chirality—is fundamental for researchers. By partnering with reliable manufacturers and suppliers, R&D professionals can efficiently acquire this essential compound, driving innovation in drug discovery and chemical synthesis. We are dedicated to being your trusted source for this vital intermediate.