For chemists and formulators, selecting the appropriate grade of a chemical intermediate is crucial for the success of their synthesis and product development. 2-Propanethiol (CAS 75-33-2), also known as isopropyl mercaptan, is no exception. This fine chemical’s utility in demanding applications, particularly in pharmaceutical synthesis, hinges on its purity and adherence to specific technical specifications. Understanding these details allows procurement professionals and R&D scientists to make informed decisions when they look to buy 2-Propanethiol.

The Importance of Purity in 2-Propanethiol
The purity of 2-Propanethiol is its most critical specification. While industrial grades might suffice for some applications, pharmaceutical intermediates typically require higher purity levels to ensure the absence of unwanted byproducts and contaminants that could interfere with sensitive reactions or compromise the safety and efficacy of the final product. Most reputable manufacturers offer 2-Propanethiol with a minimum assay of 97.0% or, more commonly for pharmaceutical applications, 99.0% or higher. This high purity is essential for reactions like the synthesis of cysteine derivatives, where even trace impurities can lead to side reactions or reduced yields.

Key Technical Specifications to Consider
Beyond assay, several other technical specifications are important when evaluating 2-Propanethiol:

  • Appearance: Typically described as a colorless liquid, any deviation from this may indicate contamination or degradation.
  • Molecular Formula and Weight: C3H8S and approximately 76.16 g/mol, respectively. These are fundamental identifiers.
  • Boiling Point: Typically around 57-60°C. This impacts handling and distillation processes.
  • Melting Point: A very low melting point of -131°C indicates it remains liquid under most ambient conditions.
  • Flash Point: A low flash point (e.g., < -30°F or <-34°C) signifies high flammability, mandating strict safety protocols.
  • Odor: Known for its strong, unpleasant odor, which is a characteristic property.
  • Solubility: Slightly soluble in water, but soluble in many organic solvents.

These parameters are critical for process design, safety assessments, and compatibility studies. When you request a quote for 2-Propanethiol, ensure the supplier provides detailed specifications for these properties.

Selecting the Right Grade and Supplier
When sourcing 2-Propanethiol, it is crucial to match the product's specifications with your application's requirements. For pharmaceutical research and manufacturing, opting for a 99% minimum purity grade is generally recommended. Companies looking to buy 2-Propanethiol should actively seek suppliers who can provide robust quality documentation, including CoA and MSDS, and who operate under recognized quality management systems like GMP or ISO. Establishing a relationship with a reliable manufacturer, potentially from regions like China known for cost-effective production and scaled capacity, can ensure both quality and consistent supply.

The Impact of Specifications on Synthesis Outcomes
Adhering to the correct specifications for 2-Propanethiol directly influences the efficiency and outcome of your synthesis. Using an intermediate with an insufficient purity level can lead to lower yields, difficulties in purification, and potentially the introduction of undesired side products into your final active pharmaceutical ingredient (API) or other specialty chemical. Therefore, investing in high-quality 2-Propanethiol from a reputable supplier is an investment in the success of your project.

In conclusion, a thorough understanding of 2-Propanethiol's specifications and purity grades is essential for any chemist or procurement specialist. By carefully evaluating product details and supplier credentials, businesses can ensure they procure the right chemical for their needs, optimizing synthesis outcomes and maintaining high standards of quality and safety.