L-Diethyl L-tartrate, identified by CAS number 87-91-2, is a chemical compound that garners significant attention in the fine chemical and pharmaceutical industries due to its distinct chiral properties and versatile applications. As a leading manufacturer and supplier, we offer this high-purity liquid intermediate, understanding its critical role in advanced chemical processes. This article will explore the essential chemical and physical characteristics of L-Diethyl L-tartrate and its diverse industrial uses, providing valuable insights for procurement managers and R&D scientists.

Chemical and Physical Profile of L-Diethyl L-tartrate

The molecular formula of L-Diethyl L-tartrate is C8H14O6, with a molecular weight of 206.193 g/mol. It is classified as a colorless to light yellow transparent liquid, making it amenable to various handling and processing techniques. Key physical properties include a density of 1.204 g/cm³, a high boiling point of 280 °C, and a melting point of 17 °C. Its flash point is 93 °C, and its vapor pressure is negligible at room temperature (0.0±1.3 mmHg at 25°C), indicating good stability.

However, the most defining characteristic of L-Diethyl L-tartrate is its chirality. With a specific rotation typically ranging from +25° to +27°, it signifies its ability to rotate plane-polarized light in a specific direction. This optical activity is crucial for its use in stereoselective synthesis. Furthermore, its moisture content is kept low, usually ≤0.5%, which is vital for maintaining its reactivity and purity during storage and application. For quality assurance, manufacturers often provide detailed specifications on assay (≥99.0%) and purity.

Industrial Applications: A Multifaceted Intermediate

The primary industrial application for L-Diethyl L-tartrate lies in its role as a chiral intermediate in the synthesis of pharmaceuticals. Most notably, it is a key building block for Posaconazole, an important antifungal medication. The precise chiral structure of L-Diethyl L-tartrate is essential for ensuring the correct stereochemistry of the final drug, directly impacting its safety and efficacy. This makes it a highly sought-after material for pharmaceutical manufacturers.

Beyond pharmaceutical synthesis, L-Diethyl L-tartrate is extensively used in asymmetric catalysis and synthesis. It serves as a chiral ligand or auxiliary in reactions designed to produce enantiomerically pure compounds. For instance, it is a critical component in the Sharpless asymmetric epoxidation, a Nobel Prize-winning reaction that transforms allylic alcohols into chiral epoxides with high stereoselectivity. This versatility makes it invaluable for researchers developing new chiral drugs, fine chemicals, and specialized materials.

Sourcing L-Diethyl L-tartrate from a Trusted Manufacturer

For businesses requiring L-Diethyl L-tartrate, identifying a reliable manufacturer and supplier is key to ensuring product quality, consistent availability, and competitive pricing. When you choose to buy L-Diethyl L-tartrate, consider factors such as:

  • Product Specifications: Confirm the assay, specific rotation, and moisture content meet your process needs.
  • Quality Control: Look for suppliers with robust quality assurance systems and readily available Certificates of Analysis.
  • Supply Chain Reliability: Partner with suppliers who can guarantee timely delivery and consistent stock availability.
  • Technical Support: Choose suppliers who offer responsive customer service and technical assistance.

As a dedicated supplier of high-quality chemical intermediates, we are committed to meeting the stringent requirements of industries that rely on precise chiral molecules. We invite you to contact us for a quote and to learn more about how our L-Diethyl L-tartrate can enhance your synthetic processes.