L-Histidine, a proteinogenic amino acid with the CAS number 71-00-1, is a molecule of significant interest across various scientific and industrial domains. Its unique chemical structure, featuring an imidazole side chain, endows it with properties that are crucial for its role in biological systems and its utility as a pharmaceutical intermediate and biochemical reagent. Understanding these chemical characteristics is key for R&D scientists and product formulators seeking to leverage L-Histidine effectively.

Chemically, L-Histidine is characterized by its molecular formula C6H9N3O2 and a molecular weight of approximately 155.15 g/mol. It exists as a solid, typically appearing as white crystals or crystalline powder. The imidazole ring in its side chain is weakly basic, allowing it to act as a buffer in biological systems and participate in metal ion coordination. This amphoteric nature means it can accept or donate protons, contributing to its involvement in enzymatic catalysis and protein structure stabilization. The pKa values associated with its functional groups are critical for understanding its behavior in different pH environments, which is vital when considering it as a pharmaceutical intermediate or for use in biochemical assays.

The applications of L-Histidine are broad and impactful. Primarily, it serves as a vital pharmaceutical intermediate in the synthesis of various drugs and therapeutic agents. Its presence in carnosine, an antioxidant dipeptide found in muscle and brain tissue, highlights its role in cellular protection and performance enhancement. As a precursor to histamine, it is involved in immune responses and neurotransmission. Furthermore, L-Histidine's ability to chelate metal ions makes it important in the transport of essential metals like copper within the body and in the function of metalloenzymes. For procurement managers looking to buy L-Histidine, understanding these applications underscores the importance of sourcing high-purity material from reliable manufacturers and suppliers.

The physical properties of L-Histidine, such as its melting point (around 282 °C with decomposition) and solubility (moderately soluble in water), are also important considerations for formulators. When sourcing from China, partnering with a reputable supplier ensures that the L-Histidine meets stringent purity requirements (>99%) and adheres to international standards, facilitating its seamless integration into complex synthesis pathways and product formulations. Reliable L-Histidine manufacturers in China provide not only the chemical itself but also the assurance of quality and consistency needed for demanding industries.