For research and development scientists focused on virology and infectious diseases, understanding the nuances of potent antiviral agents is crucial. Letermovir (CAS 917389-32-3) stands out as a key compound in the fight against cytomegalovirus (CMV). This article delves into the chemical and biological properties of Letermovir, highlighting its significance for researchers and developers seeking to buy high-quality materials from trusted suppliers.

Chemical Profile of Letermovir

Letermovir, with the molecular formula C29H28F4N4O4 and a molecular weight of 572.55 g/mol, is typically supplied as a white or off-white powder. Its CAS number, 917389-32-3, is the key identifier for sourcing. The compound exhibits good solubility in organic solvents like DMSO and ethanol, which is advantageous for laboratory experiments and formulation studies. Ensuring the purity, often specified as >99% by HPLC, is vital for reproducible research outcomes. As a dedicated chemical supplier, we ensure that our Letermovir meets these exacting standards, providing essential data such as COAs and MSDS upon request.

Biological Activity and Mechanism of Action

Letermovir's primary biological function is its potent and selective inhibition of the human cytomegalovirus (HCMV) viral terminase complex. Unlike older antivirals that target DNA polymerase, Letermovir's unique mechanism involves interfering with the cleavage and packaging of viral DNA. This makes it particularly valuable in combating CMV strains that have developed resistance to existing treatments. Its efficacy, demonstrated by low nanomolar EC50 values against various CMV isolates, underscores its importance in antiviral research. Scientists can purchase Letermovir for in vitro studies, drug discovery programs, and mechanism-of-action investigations.

Applications in Research and Development

The specific action of Letermovir against CMV makes it an indispensable tool for researchers exploring:

  • CMV Viral Replication Pathways: Understanding how Letermovir interacts with the terminase complex can unlock new insights into CMV replication.
  • Antiviral Drug Discovery: Its novel mechanism serves as a benchmark and a potential lead compound for developing next-generation antivirals against other herpesviruses.
  • Pharmacokinetic and Resistance Studies: Investigating Letermovir's bioavailability, metabolism, and the development of resistance provides critical data for clinical applications.

For R&D professionals looking to source Letermovir, it is important to find a Letermovir manufacturer that can guarantee product consistency and provide necessary technical support. Our company, as a leading supplier in China, is equipped to meet these demands, offering competitive prices and reliable delivery for your research needs. Buy Letermovir with confidence from a partner dedicated to scientific advancement.