For research chemists and formulators, understanding the synthetic potential of key intermediates is vital for innovation. 2-Amino-4-bromobenzoic acid (CAS 20776-50-5) is a prime example of a versatile building block that facilitates complex organic syntheses. Its unique combination of functional groups—an amino group, a carboxylic acid, and a bromine atom on an aromatic ring—makes it a highly reactive and valuable compound. As a dedicated manufacturer and supplier, we aim to highlight the advanced applications of this intermediate, supporting your R&D endeavors.

Ullmann-Goldberg Coupling and Heterocyclic Synthesis: A significant application of 2-Amino-4-bromobenzoic acid lies in copper-mediated Ullmann-Goldberg reactions. This methodology is instrumental in constructing nitrogen- and oxygen-containing heterocycles, such as benzoxazepines and dibenzofurans. The aryl bromide moiety readily participates in C–N and C–O bond formation under catalytic copper systems, often enhanced by specific ligands for improved enantioselectivity. This process is crucial for synthesizing compounds with complex architectures, often found in pharmaceuticals and advanced materials. Researchers seeking to buy this intermediate for such precise reactions can rely on our consistent supply.

Copper-Catalyzed Cross-Coupling for Aromatic Systems: The ortho-bromo and amino/carboxy substituents in 2-Amino-4-bromobenzoic acid enable chelation-directed cross-coupling reactions. Utilizing copper catalysis with reagents like diaryliodonium salts allows for regioselective arylation at the C–Br bond, forming biaryl ethers or N-aryl amines. These reactions often proceed under mild conditions and tolerate a wide range of functional groups, making them highly efficient for creating functionalized aromatic systems. The ability to manipulate these bonds is key for many product development pathways in our customer base.

Microwave-Assisted Synthesis Benefits: The efficiency of reactions involving 2-Amino-4-bromobenzoic acid can be dramatically enhanced through microwave irradiation. Techniques like Ullmann ether synthesis and cyclodehydration reactions can be completed in minutes rather than hours, often with higher yields and reduced side reactions. This acceleration is particularly valuable for laboratories focused on high-throughput synthesis or rapid process optimization. As a chemical supplier, we encourage our clients to explore these advanced techniques with our reliable intermediates.

Supplier Support for Your Research: Whether your focus is on developing new pharmaceuticals, innovative agrochemicals, or novel dyestuffs, 2-Amino-4-bromobenzoic acid is an indispensable tool. We are committed to being your trusted partner by providing this high-quality intermediate. If you are looking to purchase this compound for your next project, consider us your go-to manufacturer for both quality and reliability. We invite you to inquire about our product specifications, pricing, and bulk order options to support your critical synthesis needs.