In the relentless pursuit of effective cancer therapies, understanding and targeting the unique metabolic pathways of cancer cells is paramount. Among the most critical pathways is glycolysis, often hyperactivated in tumors – a phenomenon known as the Warburg effect. At the forefront of research into glycolysis inhibition is Lonidamine, a compound whose precise mechanism offers invaluable insights for drug development and scientific inquiry.

Lonidamine, chemically identified as 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid (CAS 50264-69-2), stands out as a potent inhibitor of hexokinase. Hexokinase is the enzyme responsible for the initial step of glycolysis, phosphorylating glucose to glucose-6-phosphate. By inactivating this crucial enzyme, Lonidamine effectively disrupts the energy supply chain for cancer cells, which heavily rely on glycolysis for survival and proliferation. This targeted disruption is central to its anticancer activity.

The significance of Lonidamine extends beyond just blocking glycolysis. Research indicates that it plays a crucial role in inducing apoptosis, or programmed cell death. Studies have shown that Lonidamine can trigger markers of mitochondrial membrane depolarization, leading to the release of cytochrome C and subsequent DNA fragmentation. This multifaceted action makes it a compound of great interest for researchers investigating cell death pathways and novel therapeutic strategies.

For scientists requiring this critical research tool, sourcing high-purity Lonidamine from a reliable manufacturer is essential. As a leading supplier of pharmaceutical intermediates and specialty chemicals from China, we understand the importance of consistency and quality. Our Lonidamine boasts a purity of ≥98%, ensuring that your research is built upon a foundation of dependable reagents. We are committed to providing competitive lonidamine price options, especially for bulk purchases, making advanced research more accessible.

Researchers looking to buy Lonidamine for their studies in oncology, metabolism, or apoptosis will find our offering to be of exceptional value. The ability to purchase directly from a manufacturer eliminates intermediaries, ensuring both quality control and cost-effectiveness. If you are seeking a trusted lonidamine supplier, we invite you to contact us for a quote and to learn more about how our high-quality Lonidamine can support your groundbreaking research. Understanding and inhibiting cellular energy metabolism is key to unlocking new treatments, and Lonidamine is a vital component in this scientific endeavor.