Loratadine CAS 79794-75-5 is a well-established pharmaceutical intermediate, prized for its role in developing effective treatments for allergies. As a leading chemical manufacturer, understanding the detailed specifications and properties of Loratadine is crucial for R&D scientists and product formulators aiming to create safe and potent anti-allergic medications. This article delves into the chemical profile and primary applications of Loratadine.

Chemically, Loratadine is identified by the CAS number 79794-75-5 and possesses the molecular formula C22H23ClN2O2. Its physical form is typically a white or almost white powder, with a specified purity of ≥99.00%. This high level of purity is critical for pharmaceutical applications, ensuring minimal impurities that could affect the efficacy or safety of the final drug product. The molecular weight of Loratadine is approximately 382.88 g/mol, and it has a melting point range of 134-136°C, indicating its solid state under standard conditions.

The solubility profile of Loratadine is also noteworthy for formulators. It is soluble in solvents like DMSO (50 mg/ml) and ethanol (77 mg/ml at 25°C), moderately soluble in water (<1 mg/ml at 25°C), and also shows solubility in chloroform and methanol. This range of solubility allows for flexibility in various formulation processes. The stability of Loratadine is generally good, though it may be heat-sensitive and should be stored under recommended conditions, typically between 2-8°C, and kept away from strong oxidizing agents.

The primary application of Loratadine is as an anti-histamine drug. By competitively inhibiting histamine H1 receptors, it effectively blocks the cascade of allergic reactions, providing relief from symptoms such as sneezing, runny nose, itchy throat, and itchy eyes associated with conditions like allergic rhinitis and hay fever. It is also widely used in the treatment of urticaria (hives) and other allergic skin conditions. For pharmaceutical companies, this means Loratadine is a vital component in the manufacturing of effective allergy relief medications.

As a direct manufacturer and supplier of Loratadine CAS 79794-75-5, we offer this essential chemical intermediate at competitive prices. If your research and development or manufacturing processes require a reliable source of high-purity Loratadine, we encourage you to contact us for a detailed quote. Understanding the chemical properties and application potential of Loratadine is key to leveraging its therapeutic benefits in your pharmaceutical products. Let us be your trusted supplier for this critical API intermediate.