For the pharmaceutical industry, the consistent and reliable sourcing of high-quality chemical intermediates is fundamental to drug development and manufacturing. 2-Acetylhydroquinone, known chemically as 2',5'-Dihydroxyacetophenone (CAS 490-78-8), is a critical compound utilized in the synthesis of various pharmaceutical agents. Procurement professionals and R&D scientists in this sector must understand the stringent requirements for sourcing such materials. This article provides insights for pharmaceutical companies looking to buy 2-Acetylhydroquinone from manufacturers, emphasizing quality standards, supply chain integrity, and competitive pricing.

The Role of 2-Acetylhydroquinone in Pharmaceuticals

2-Acetylhydroquinone (CAS 490-78-8) serves as a valuable building block in complex organic synthesis pathways relevant to drug discovery and production. Its specific chemical structure, featuring hydroxyl and ketone groups, allows for targeted reactions to create sophisticated molecular architectures found in many active pharmaceutical ingredients (APIs). The demand for this compound is driven by its role as an intermediate in creating molecules with therapeutic properties. Therefore, ensuring its purity and consistent quality is paramount for the success of any pharmaceutical synthesis project.

Ensuring Pharmaceutical-Grade Quality: USP, BP, FCC Standards

When a pharmaceutical company decides to buy 2-Acetylhydroquinone, adherence to pharmacopeial standards is non-negotiable. The mention of USP (United States Pharmacopeia), BP (British Pharmacopoeia), and FCC (Food Chemicals Codex) grades indicates that the product has been manufactured and tested to meet rigorous international quality and safety benchmarks. These standards ensure:

  • High Purity: Minimizing impurities that could affect downstream reactions or the final drug product's safety and efficacy.
  • Consistency: Batch-to-batch uniformity in chemical composition and physical properties.
  • Safety: Absence of harmful contaminants and compliance with regulatory guidelines.

Procurement specialists should always request a Certificate of Analysis (CoA) from the supplier that explicitly states the product meets the required pharmacopeial grade. This documentation is essential for regulatory submissions and internal quality control.

Working with Manufacturers: Pricing and Supply Chain

For pharmaceutical manufacturers, establishing direct relationships with reputable chemical manufacturers is key to securing a stable and cost-effective supply of 2-Acetylhydroquinone. Manufacturers in China, for instance, can offer competitive pricing, often quoted in ranges like $0-$99/kg FOB China, depending on the volume and specific grade. When placing an order, typical packaging is in 25kg drums, but manufacturers can often accommodate specific packaging requests. Understanding the manufacturer's production capacity and lead times is vital for supply chain planning. A factory site in Hefei, for example, signifies established manufacturing capabilities.

The Procurement Process: Inquiry to Delivery

To buy 2-Acetylhydroquinone for pharmaceutical use, initiate contact with potential suppliers. Clearly state your requirements: product name (2',5'-Dihydroxyacetophenone), CAS number (490-78-8), desired grade (USP/BP/FCC), quantity, and any specific delivery or packaging needs. Reputable suppliers will provide prompt responses, detailed product information, and competitive quotes. It is also advisable to inquire about obtaining samples for preliminary testing and verification before committing to a large purchase order.

By diligently focusing on quality standards, supply chain reliability, and competitive pricing, pharmaceutical companies can effectively source 2-Acetylhydroquinone (CAS 490-78-8) to support their critical drug development and manufacturing processes.