The reliable supply of high-quality pharmaceutical intermediates hinges on manufacturing excellence. For N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-2-propenamide (CAS 130929-57-6), a compound critical to advanced drug synthesis, understanding its manufacturing process is key for both producers and purchasers. This article delves into the chemical synthesis and quality assurance practices that define its production.

Chemical Synthesis Pathways

The synthesis of N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-2-propenamide typically follows established organic chemistry principles. A common route involves the condensation reaction between 3,4-dihydroxy-5-nitrobenzaldehyde and N,N-diethyl-2-cyanoacetamide. This reaction is often catalyzed by agents like piperidine acetate, and carried out in suitable organic solvents such as ethanol. Following the initial reaction, purification steps are critical to isolate the desired product and remove impurities or by-products, such as isomers or unreacted starting materials.

Key Steps in Production:

  • Reactant Preparation: Ensuring the purity and precise measurement of starting materials like 3,4-dihydroxy-5-nitrobenzaldehyde and N,N-diethyl-2-cyanoacetamide.
  • Condensation Reaction: Controlled reaction conditions (temperature, time, catalyst) are essential to maximize yield and minimize side reactions.
  • Purification: Recrystallization, chromatography, or other separation techniques are employed to achieve the required high purity levels (>98%).
  • Drying and Packaging: The final product is dried under vacuum and packaged appropriately to maintain stability during storage and transport.

Quality Control Measures

Manufacturing excellence for CAS 130929-57-6 extends beyond synthesis to robust quality control (QC). Reputable manufacturers implement rigorous QC protocols at various stages of production:

  • Raw Material Testing: Verifying the quality of incoming raw materials.
  • In-Process Controls: Monitoring reaction progress and intermediate purity.
  • Final Product Analysis: Comprehensive testing of the finished product using techniques such as HPLC (for purity), NMR (for structural confirmation), and Karl Fischer titration (for moisture content).
  • Batch Traceability: Maintaining detailed records for each production batch to ensure full traceability.

Partnering for Production Excellence

For pharmaceutical companies seeking to buy N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-2-propenamide, partnering with manufacturers who prioritize these manufacturing and QC standards is paramount. It ensures the availability of a reliable, high-quality intermediate essential for the development of life-changing medicines.

Conclusion

The production of N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-2-propenamide (CAS 130929-57-6) demands meticulous chemical synthesis and stringent quality control. As a leading manufacturer, we pride ourselves on our production capabilities and commitment to delivering intermediates that meet the highest industry standards. Contact us to learn more about our manufacturing processes and to inquire about bulk purchasing.