Solid-phase peptide synthesis (SPPS) is a cornerstone technique in biochemistry, drug discovery, and materials science. The Fmoc (9-fluorenylmethoxycarbonyl) strategy is particularly favored for its mild deprotection conditions, making it suitable for a wide range of sensitive amino acid side chains. Central to this methodology are protected amino acid building blocks, and N-alpha-Fmoc-Ndelta-Boc-L-ornithine (CAS 109425-55-0) is a prime example of a critical reagent for advanced peptide construction.

N-alpha-Fmoc-Ndelta-Boc-L-ornithine is a derivative of L-ornithine, an amino acid not found in proteins but crucial for various biological functions and synthetic peptide design. In this protected form, the alpha-amino group is masked by the Fmoc moiety, allowing it to participate in standard peptide bond formation during SPPS. Concurrently, the delta-amino group, located on the side chain, is protected by the tert-butoxycarbonyl (Boc) group. This orthogonal protection is key: the Fmoc group is readily removed by a mild base (like piperidine), enabling the addition of the next amino acid, while the Boc group remains stable under these conditions. It can be selectively removed later, often with an acid like trifluoroacetic acid (TFA), which is typically used in the final cleavage of the peptide from the resin.

The strategic use of N-alpha-Fmoc-Ndelta-Boc-L-ornithine is particularly beneficial when synthesizing peptides that require ornithine incorporation for specific structural or functional purposes. This includes the formation of cyclic peptides, where the delta-amino group of ornithine can be used to form a lactam bridge with a carboxyl group on another residue. Such cyclic structures often exhibit enhanced stability against enzymatic degradation and can adopt specific conformations important for receptor binding or enzyme inhibition. Researchers looking to buy N-alpha-Fmoc-Ndelta-Boc-L-ornithine are typically engaged in these sophisticated synthesis projects.

For optimal results in Fmoc SPPS, the purity and quality of the amino acid derivatives are paramount. Impurities can lead to truncated sequences, deletions, or side reactions, complicating purification and reducing the yield of the desired peptide. Therefore, sourcing N-alpha-Fmoc-Ndelta-Boc-L-ornithine from a reputable manufacturer or supplier is essential. Companies like NINGBO INNO PHARMCHEM CO.,LTD., a leading supplier in China, specialize in providing high-purity reagents that meet stringent quality standards, ensuring reliability for your research. Obtaining a quote from such suppliers provides clarity on the price and availability.

When considering the procurement of this reagent, factors such as lot-to-lot consistency, assay values, and storage recommendations (typically 2-8°C) should be carefully reviewed. The correct handling and storage of N-alpha-Fmoc-Ndelta-Boc-L-ornithine will preserve its integrity and ensure its effectiveness in synthesis. For laboratories requiring substantial quantities, understanding the bulk price from a direct manufacturer can offer significant cost savings. This makes it easier to purchase the necessary materials for larger-scale peptide production or extensive research programs.

In summary, N-alpha-Fmoc-Ndelta-Boc-L-ornithine is a versatile and critical building block for mastering Fmoc solid-phase peptide synthesis, especially for creating peptides with unique structural features like cyclic peptides. By partnering with trusted manufacturers and suppliers, researchers can ensure they are using high-quality reagents, paving the way for successful and efficient peptide synthesis.