For organic chemists, the ability to efficiently synthesize complex molecules relies heavily on the availability of versatile and well-characterized building blocks. 5-Bromopyridine-2-carboxylic acid (CAS: 30766-11-1) is one such indispensable intermediate. Its unique combination of a pyridine ring, a bromine atom, and a carboxylic acid group provides chemists with a reactive platform for a multitude of transformations. This article explores the key chemical properties and fundamental synthetic techniques associated with this essential compound.

The physical and chemical properties of 5-Bromopyridine-2-carboxylic acid are critical for its effective use in synthesis. Appearing as a white to light yellow powder, it boasts a melting point of 173-175°C, indicating reasonable thermal stability. Its solubility in polar solvents like methanol aids in reaction setup and workup procedures. The compound's high purity, typically ≥99.0%, is a testament to its quality and suitability for demanding synthetic protocols. When researchers plan to buy 5-bromopyridine-2-carboxylic acid, they are seeking a material that guarantees predictable reactivity and minimal side reactions.

Mastering organic synthesis with this compound involves understanding its reactivity in various reactions. It readily participates in nucleophilic substitution reactions at the bromine site and can undergo coupling reactions, such as Suzuki-Miyaura, to form new carbon-carbon bonds. The carboxylic acid group can be esterified, reduced, or converted into other functional groups. Understanding the established 5-bromopyridine-2-carboxylic acid synthesis methods is also crucial for sourcing and optimizing its use. The diverse uses of 5-bromo-picolinic acid in creating intricate molecular architectures highlight its importance in modern chemical research and development, making it a staple in many synthetic laboratories.