In the intricate world of peptide synthesis, the selection of high-quality protected amino acids is paramount to achieving successful and reproducible results. Among these essential building blocks, Boc-Cys(Acm)-OH stands out for its critical role in constructing complex peptide structures, particularly cyclic peptides that feature disulfide bonds. For researchers and formulators, understanding the properties and procurement of this key intermediate is vital.

Boc-Cys(Acm)-OH, also known by its systematic name N-Boc-S-acetamidomethyl-L-cysteine, provides a protected form of cysteine that allows for controlled incorporation into growing peptide chains. The tert-Butoxycarbonyl (Boc) group protects the alpha-amino group, while the acetamidomethyl (Acm) group safeguards the thiol side chain of cysteine. This dual protection is essential for preventing unwanted side reactions during peptide assembly.

The true value of Boc-Cys(Acm)-OH lies in its utility for creating disulfide bridges, which are crucial for the structural integrity and biological activity of many peptides. After peptide chain elongation, the Acm group can be selectively removed, typically using reagents like iodine or mercuric salts, followed by oxidation to form the disulfide bond. This process is a cornerstone in the synthesis of many therapeutic peptides and proteins.

For procurement professionals and R&D scientists, sourcing Boc-Cys(Acm)-OH from a reliable manufacturer is non-negotiable. Companies seeking to buy this compound often look for high purity, consistent lot-to-lot quality, and competitive pricing. Understanding the chemical properties, such as its appearance as a white powder and its CAS number (19746-37-3), is the first step in evaluating a potential supplier. Manufacturers play a crucial role in ensuring that these intermediates meet stringent specifications required for pharmaceutical and biotechnological applications.

When considering where to purchase Boc-Cys(Acm)-OH, it is beneficial to partner with suppliers who specialize in amino acid derivatives and peptide synthesis reagents. A reputable manufacturer will not only provide the material but also offer technical support and a stable supply chain, which is critical for ongoing research and production. Exploring options to buy in bulk can also lead to significant cost savings, making it easier to manage project budgets.

In summary, Boc-Cys(Acm)-OH is an indispensable component for advanced peptide synthesis, enabling the creation of peptides with specific structures and functionalities. For researchers and developers, securing a dependable supply of this high-quality reagent from a trusted manufacturer is key to advancing their projects in peptide drug discovery and biochemical research.