Mastering Peptide Synthesis: A Guide to N-Carbobenzyloxy-L-aspartic Acid
Peptide synthesis is a cornerstone of modern biotechnology and pharmaceutical research. Central to this process are protected amino acids, which allow for the controlled assembly of amino acid chains. Among these crucial building blocks is N-Carbobenzyloxy-L-aspartic acid, commonly known as Z-Asp-OH or Cbz-Asp-OH, with the CAS number 1152-61-0. NINGBO INNO PHARMCHEM CO.,LTD. is proud to be a leading supplier of this high-quality fine chemical intermediate.
N-Carbobenzyloxy-L-aspartic acid is an N-protected derivative of the non-essential amino acid L-aspartic acid. The carbobenzyloxy (Cbz or Z) group serves as a protecting group for the amine functionality. This protection is vital because it prevents unwanted side reactions during the peptide coupling steps. The carboxyl groups of aspartic acid, however, are typically left unprotected or may be selectively protected as esters for specific synthetic strategies.
The synthesis of N-Carbobenzyloxy-L-aspartic acid generally involves the reaction of L-Aspartic acid with Benzyl chloroformate in the presence of a base. This reaction yields the desired protected amino acid, which is then purified to meet stringent quality standards, such as USP, BP, or FCC grades. As a manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. ensures that our product exhibits high purity, which is paramount for successful peptide synthesis outcomes. We provide this essential amino acid derivative at a competitive price, making it accessible for various research and industrial applications.
The primary application of N-Carbobenzyloxy-L-aspartic acid is in peptide synthesis, both in solution phase and solid-phase peptide synthesis (SPPS). It acts as a monomer that can be sequentially added to a growing peptide chain. The Cbz group can be conveniently removed under mild hydrogenolysis conditions, revealing the free amine for the next coupling reaction. This controlled deprotection strategy is fundamental to building accurate and complex peptide sequences.
Beyond its role in peptide synthesis, N-Carbobenzyloxy-L-aspartic acid also finds use as a building block in the synthesis of other complex organic molecules and is relevant in pharmaceutical research for developing novel therapeutics. The availability of this compound from reliable suppliers like NINGBO INNO PHARMCHEM CO.,LTD. is critical for researchers to purchase N-Carbobenzyloxy-L-aspartic acid and advance their work.
For those looking to buy N-Carbobenzyloxy-L-aspartic acid, sourcing from a reputable manufacturer in China ensures quality and cost-effectiveness. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing exceptional service and high-purity fine chemicals. We invite you to explore our product offerings and discover how our commitment to excellence can support your research and manufacturing needs. Partner with us for your N-Carbobenzyloxy-L-aspartic acid requirements and experience the difference quality sourcing makes.
N-Carbobenzyloxy-L-aspartic acid is an N-protected derivative of the non-essential amino acid L-aspartic acid. The carbobenzyloxy (Cbz or Z) group serves as a protecting group for the amine functionality. This protection is vital because it prevents unwanted side reactions during the peptide coupling steps. The carboxyl groups of aspartic acid, however, are typically left unprotected or may be selectively protected as esters for specific synthetic strategies.
The synthesis of N-Carbobenzyloxy-L-aspartic acid generally involves the reaction of L-Aspartic acid with Benzyl chloroformate in the presence of a base. This reaction yields the desired protected amino acid, which is then purified to meet stringent quality standards, such as USP, BP, or FCC grades. As a manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. ensures that our product exhibits high purity, which is paramount for successful peptide synthesis outcomes. We provide this essential amino acid derivative at a competitive price, making it accessible for various research and industrial applications.
The primary application of N-Carbobenzyloxy-L-aspartic acid is in peptide synthesis, both in solution phase and solid-phase peptide synthesis (SPPS). It acts as a monomer that can be sequentially added to a growing peptide chain. The Cbz group can be conveniently removed under mild hydrogenolysis conditions, revealing the free amine for the next coupling reaction. This controlled deprotection strategy is fundamental to building accurate and complex peptide sequences.
Beyond its role in peptide synthesis, N-Carbobenzyloxy-L-aspartic acid also finds use as a building block in the synthesis of other complex organic molecules and is relevant in pharmaceutical research for developing novel therapeutics. The availability of this compound from reliable suppliers like NINGBO INNO PHARMCHEM CO.,LTD. is critical for researchers to purchase N-Carbobenzyloxy-L-aspartic acid and advance their work.
For those looking to buy N-Carbobenzyloxy-L-aspartic acid, sourcing from a reputable manufacturer in China ensures quality and cost-effectiveness. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing exceptional service and high-purity fine chemicals. We invite you to explore our product offerings and discover how our commitment to excellence can support your research and manufacturing needs. Partner with us for your N-Carbobenzyloxy-L-aspartic acid requirements and experience the difference quality sourcing makes.
Perspectives & Insights
Quantum Pioneer 24
“is proud to be a leading supplier of this high-quality fine chemical intermediate.”
Bio Explorer X
“N-Carbobenzyloxy-L-aspartic acid is an N-protected derivative of the non-essential amino acid L-aspartic acid.”
Nano Catalyst AI
“The carbobenzyloxy (Cbz or Z) group serves as a protecting group for the amine functionality.”