Peptide synthesis is a cornerstone of modern biotechnology and pharmaceutical development. Achieving high yields and purity in peptide chains hinges on the selection of appropriate reagents, among which N-Acetoxysuccinimide (CAS 14464-29-0) plays a pivotal role. As a key intermediate, its effectiveness is paramount for researchers and manufacturers aiming to produce complex peptides for therapeutic or research purposes.

N-Acetoxysuccinimide, often referred to by its synonyms like N-Succinimidyl Acetate or Acetic Acid NHS ester, is characterized by its white crystalline powder appearance and a high purity level, typically exceeding 98.0% as determined by HPLC. This high purity is critical because impurities can lead to side reactions, reducing the yield and quality of the synthesized peptide. For procurement managers and R&D scientists, sourcing a consistent, high-purity supply is a priority.

The primary function of N-Acetoxysuccinimide in peptide synthesis is as an activating agent. It reacts with carboxylic acids to form activated esters that are highly reactive towards amines. This activation is a crucial step in forming peptide bonds, where the amine group of one amino acid attacks the activated carboxyl group of another. The succinimidyl group serves as an excellent leaving group, facilitating efficient coupling with minimal racemization, a common challenge in peptide chemistry.

When considering where to buy N-Acetoxysuccinimide, particularly in bulk quantities, sourcing from a reputable manufacturer in China can offer significant advantages in terms of cost-effectiveness and scalability. Many international research institutions and pharmaceutical companies rely on Chinese chemical suppliers for their consistent quality and competitive pricing. For example, purchasing N-Acetoxysuccinimide in China can streamline your supply chain and reduce overall production costs.

Beyond its direct role in peptide bond formation, N-Acetoxysuccinimide also finds applications in bioconjugation. It can be used to modify proteins, antibodies, or other biomolecules by introducing acetyl groups or by serving as a precursor for other functionalization reactions. This versatility makes it an indispensable tool for researchers in fields such as diagnostics, drug delivery, and molecular imaging.

For those looking to purchase N-Acetoxysuccinimide, understanding its properties is key. It is a moisture-sensitive compound, requiring proper storage conditions, typically in a cool, dry environment, often under an inert atmosphere, and refrigerated. This characteristic underscores the importance of receiving the product in well-sealed packaging from a trusted supplier who maintains appropriate handling and storage protocols throughout the supply chain.

In summary, N-Acetoxysuccinimide (CAS 14464-29-0) is an essential reagent for peptide synthesis and bioconjugation. Its high purity, reactivity, and versatility make it a valuable asset for any research or production facility. If you are seeking a reliable supplier for N-Acetoxysuccinimide in China, exploring options that offer competitive pricing and guaranteed quality is a strategic move for your ongoing projects.