In the intricate world of peptide synthesis, the quality and purity of the building blocks are paramount. For professionals engaged in solid-phase peptide synthesis (SPPS) and drug development, Fmoc-Lys(Boc)-OH stands out as an indispensable amino acid derivative. This article delves into why this specific compound is a preferred choice and what researchers and procurement managers should look for when seeking a dependable manufacturer and supplier.

Fmoc-Lys(Boc)-OH, chemically known as Nα-(9-Fluorenylmethyloxycarbonyl)-Nε-tert-butyloxycarbonyl-L-lysine, is a derivative of lysine that incorporates two crucial protecting groups. The Nα-Fmoc (9-fluorenylmethyloxycarbonyl) group is standard in SPPS, designed for facile removal under mild basic conditions (e.g., piperidine treatment). More importantly, the Nε-Boc (tert-butyloxycarbonyl) group on the side chain of lysine provides crucial protection. This dual protection strategy is key to its utility. The Nε-Boc group remains stable during the repeated Fmoc deprotection cycles, preventing unwanted side reactions on the lysine side chain. It is only removed during the final cleavage step of the peptide from the solid support, typically using trifluoroacetic acid (TFA) in conjunction with scavengers.

The primary application for Fmoc-Lys(Boc)-OH is, unequivocally, in Fmoc-based SPPS. This method is widely adopted due to its efficiency, mild reaction conditions, and suitability for automated synthesis. Lysine is a fundamental amino acid found in many biologically active peptides, often playing roles in charge, hydrophilicity, or as attachment points for further modifications. The ability to selectively deprotect the lysine side chain at the end of the synthesis is critical for these downstream modifications, such as conjugation to other molecules, formation of cyclic peptides, or incorporation into larger protein structures.

Procurement managers and research scientists often search for specific criteria when buying Fmoc-Lys(Boc)-OH. High purity is non-negotiable. Typically, a purity of ≥99% (often verified by HPLC) is sought, as impurities can lead to truncated or modified peptides, complicating purification and potentially affecting biological activity. Enantiomeric purity (≥99.8% for L-lysine) is also critical to ensure the correct stereochemistry in the final peptide product. When considering a supplier, factors like consistent batch-to-batch quality, reliable supply chains, comprehensive documentation (including Certificates of Analysis and Safety Data Sheets), and competitive pricing are paramount. Many international buyers actively search for terms like 'Fmoc-Lys(Boc)-OH price China' or 'buy Fmoc-Lys(Boc)-OH manufacturer' to identify cost-effective and reliable sources.

Beyond basic peptide synthesis, Fmoc-Lys(Boc)-OH also finds use in advanced applications such as the synthesis of peptide dendrimers, peptide-drug conjugates, and peptides for diagnostic assays. Its role in creating complex architectures underscores its importance in modern pharmaceutical research and development. As a key reagent, ensuring a stable and high-quality supply of Fmoc-Lys(Boc)-OH is essential for any laboratory or manufacturing facility involved in peptide chemistry. Partnering with reputable suppliers who can offer technical support and consistent product availability is a strategic advantage for any B2B customer.