In the complex world of pharmaceutical manufacturing, the reliability and quality of chemical intermediates are paramount. One such vital compound is 3-Amino-4-pyrazolecarbonitrile (CAS: 16617-46-2). As a leading manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-purity intermediates that drive innovation in drug discovery and production.

Understanding 3-Amino-4-pyrazolecarbonitrile

This heterocyclic compound, characterized by its pyrazole ring, amino group, and nitrile functionality, serves as a critical building block in organic synthesis. Its molecular formula, C4H4N4, and molecular weight of 108.1 g/mol, coupled with a typical purity of 97-99%, make it an ideal starting material for synthesizing more complex molecules. Available often as a yellow to brown powder or crystals, its physical form is important for handling and reaction efficiency.

Key Applications in Drug Development

The primary significance of 3-Amino-4-pyrazolecarbonitrile lies in its role as an intermediate for synthesizing active pharmaceutical ingredients (APIs). Notably, it is instrumental in the production of:

  • Zaleplon: A non-benzodiazepine hypnotic used for the short-term treatment of insomnia. The synthesis of Zaleplon heavily relies on this pyrazole derivative as a key precursor.
  • Ibrutinib: An important antineoplastic drug used to treat certain types of cancer, such as chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). This intermediate is crucial for its complex synthesis pathway.

Beyond these specific drugs, its versatile structure makes it valuable for researchers exploring new molecular entities with potential therapeutic applications in various fields of medicinal chemistry.

Synthesis Methods and Sourcing Considerations

The synthesis of 3-Amino-4-pyrazolecarbonitrile typically involves reactions with compounds like ethoxymethylene malononitrile and hydrazine hydrate. Understanding these synthesis routes can be beneficial for R&D departments and process chemists. When looking to buy this compound, sourcing from reputable manufacturers is essential. Factors to consider include:

  • Purity and Consistency: Ensuring the intermediate meets specified purity levels (e.g., >97% or >99%) is critical for reliable reaction outcomes and API quality.
  • Supply Chain Stability: Partnering with a stable supplier guarantees uninterrupted production, preventing costly delays.
  • Technical Support: Access to technical data, synthesis insights, and responsive customer service from your manufacturer can significantly streamline your procurement process.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to being your trusted partner. We offer competitive pricing for 3-Amino-4-pyrazolecarbonitrile and a commitment to quality that ensures your research and manufacturing processes are supported by the finest chemical intermediates. If you are looking to buy this essential compound, consider NINGBO INNO PHARMCHEM as your reliable manufacturer and supplier in China.

For inquiries about purchasing 3-Amino-4-pyrazolecarbonitrile, its applications, or to request a quote, please do not hesitate to contact us. We are here to support your chemical sourcing needs.