The Horner-Wadsworth-Emmons (HWE) reaction stands as a cornerstone in organic synthesis, offering a robust method for the stereoselective formation of carbon-carbon double bonds. At its heart lies a critical reagent: Triethyl Phosphonoacetate (CAS 867-13-0). As a leading manufacturer and supplier based in China, we understand the pivotal role this compound plays in your research and production. This guide delves into the application of Triethyl Phosphonoacetate in HWE reactions and highlights why sourcing from a reliable supplier is paramount for your success.

The HWE reaction, a variation of the Wittig reaction, utilizes phosphonate esters, such as Triethyl Phosphonoacetate, to react with carbonyl compounds (aldehydes and ketones). The deprotonation of Triethyl Phosphonoacetate by a suitable base generates a stabilized phosphonate carbanion. This carbanion then undergoes nucleophilic attack on the carbonyl carbon, followed by a series of intramolecular rearrangements and elimination steps to yield an alkene and a phosphate byproduct. A key advantage of using Triethyl Phosphonoacetate in HWE reactions is its tendency to predominantly form the thermodynamically more stable E-alkene, offering excellent stereochemical control. This makes it an indispensable tool for chemists aiming to buy specific alkene geometries.

For researchers and procurement managers seeking to purchase Triethyl Phosphonoacetate, understanding its properties is crucial. Our Triethyl Phosphonoacetate, manufactured under stringent quality controls, boasts a purity of ≥95%, ensuring consistent and reliable performance in your HWE transformations. The liquid form (clear colorless oil) simplifies handling and addition in reaction setups. Beyond its role in HWE reactions, this versatile chemical also serves as a vital pharmaceutical intermediate, contributing to the synthesis of a wide array of therapeutic agents. When you need to buy pharmaceutical intermediates, our product delivers the quality and consistency required for complex drug development.

The decision of where to buy Triethyl Phosphonoacetate can significantly impact your project's efficiency and cost-effectiveness. As a direct manufacturer and supplier in China, NINGBO INNO PHARMCHEM CO.,LTD. offers a distinct advantage. We provide competitive pricing without compromising on quality, ensuring you receive the best value for your investment. Our established supply chain guarantees a stable availability of Triethyl Phosphonoacetate, alleviating concerns about stockouts and delivery delays that can affect your production timelines. We are committed to being your preferred partner, offering not just a product, but a reliable supply solution. If you are looking for the best price for Triethyl Phosphonoacetate or seeking a dependable supplier, look no further.

In conclusion, Triethyl Phosphonoacetate is an essential reagent for modern organic synthesis, particularly within the framework of the Horner-Wadsworth-Emmons reaction. Its role as a pharmaceutical intermediate further solidifies its importance in the chemical industry. For procurement managers and R&D scientists who require high-purity Triethyl Phosphonoacetate, NINGBO INNO PHARMCHEM CO.,LTD. stands ready as your trusted manufacturer and supplier in China, offering quality, reliability, and competitive pricing. Contact us today for a quote and to explore how we can support your ongoing chemical needs.