NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing comprehensive information on the compounds we offer. 3-Amino-5-bromo-2-methoxypyridine is a prime example of a sophisticated organic synthesis intermediate, and understanding its synthesis, properties, and handling is crucial for its effective utilization.

The synthesis of 3-Amino-5-bromo-2-methoxypyridine typically involves a multi-step process starting from suitable pyridine derivatives. Key steps include regioselective bromination at the 5-position, followed by methoxylation at the 2-position and hydroxylation at the 3-position. Alternatively, the pyridine ring can be constructed from simpler nitrogen-containing precursors, with the functional groups introduced sequentially. Each step requires careful selection of reagents and precise control over reaction conditions, such as temperature and time, to ensure high yield and purity. Thorough separation and purification after each stage are essential to obtain the desired product free from side reactions.

Physically, 3-Amino-5-bromo-2-methoxypyridine is usually presented as a light yellow to dark brown solid. Its melting point, typically in the range of 53-55℃, and boiling point of approximately 284.5℃ at 760 mmHg, are important identifiers. Chemically, it exhibits weak basicity due to the nitrogen atom in the pyridine ring and the amino group. The bromine atom is reactive and can participate in various transformations, including metal-catalyzed coupling reactions, which are fundamental for constructing carbon-carbon bonds and expanding molecular complexity. The methoxy group influences the electron distribution within the pyridine ring, affecting its reactivity and regioselectivity in electrophilic substitution reactions.

When considering the purchase of 3-Amino-5-bromo-2-methoxypyridine, it is vital to be aware of its handling and storage requirements. The compound should be stored in a cool, dry, and well-ventilated area, away from incompatible substances like strong oxidizers and acids, to prevent degradation or hazardous reactions. Proper packaging is also essential during transportation to ensure integrity and safety. Adhering to these precautions is paramount for maintaining the quality and safety of this valuable intermediate.

Understanding the synthesis routes and chemical properties of 3-Amino-5-bromo-2-methoxypyridine enables chemists to maximize its potential in various applications, from drug discovery to material science. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supporting these endeavors by providing a reliable supply of this critical chemical.