Maximizing Drug Solubility: The Role of (2-Hydroxypropyl)-β-Cyclodextrin
In the pharmaceutical industry, the solubility of an active pharmaceutical ingredient (API) is a critical factor determining its bioavailability and therapeutic efficacy. Many promising drug candidates suffer from poor aqueous solubility, posing significant challenges in formulation development. This is where advanced excipients like (2-Hydroxypropyl)-β-Cyclodextrin, often abbreviated as HP-β-CD, play a pivotal role.
(2-Hydroxypropyl)-β-Cyclodextrin (CAS: 128446-35-5) is a modified cyclodextrin derivative that offers a unique solution to this persistent problem. Comprised of seven glucose units arranged in a toroidal structure, it possesses a hydrophobic inner cavity and a hydrophilic outer surface. This amphiphilic nature allows HP-β-CD to form stable inclusion complexes with hydrophobic drug molecules. The drug's nonpolar parts are sequestered within the cyclodextrin's cavity, effectively shielding them from the aqueous environment and thereby dramatically increasing the overall aqueous solubility of the complex.
As a leading manufacturer and supplier of HP-β-CD in China, we understand the importance of purity and consistency for pharmaceutical applications. Our (2-Hydroxypropyl)-β-Cyclodextrin boasts a purity of over 95%, ensuring reliable performance in your formulations. We are committed to providing pharmaceutical scientists and procurement managers with a high-quality, cost-effective solution. If you are looking to buy (2-Hydroxypropyl)-beta-cyclodextrin for enhanced drug solubility, our product is an excellent choice. We also offer competitive pricing and can provide free samples for your evaluation.
Beyond mere solubilization, HP-β-CD also contributes to the stabilization of drugs against degradation from light, heat, and oxidation. This leads to improved shelf-life and product integrity. Its safety profile and low toxicity make it a preferred excipient for oral, parenteral, and topical drug delivery systems. For procurement managers seeking a reliable supplier of pharmaceutical intermediates with superior solubilizing properties, our (2-Hydroxypropyl)-β-Cyclodextrin offers an ideal combination of quality and value. Inquire today for a quote and to discuss how we can meet your bulk purchasing needs.
Leveraging the benefits of HP-β-CD can significantly streamline your drug development process and lead to more effective therapeutic products. Partner with us, a trusted manufacturer in China, to secure a consistent and high-quality supply of this essential pharmaceutical excipient.
Perspectives & Insights
Core Pioneer 24
“If you are looking to buy (2-Hydroxypropyl)-beta-cyclodextrin for enhanced drug solubility, our product is an excellent choice.”
Silicon Explorer X
“We also offer competitive pricing and can provide free samples for your evaluation.”
Quantum Catalyst AI
“Beyond mere solubilization, HP-β-CD also contributes to the stabilization of drugs against degradation from light, heat, and oxidation.”