N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide: A Key Component for ADCs
The field of targeted cancer therapy is rapidly evolving, with Antibody-Drug Conjugates (ADCs) emerging as a powerful modality. At the heart of an ADC's efficacy lies the linker, a crucial component that connects the targeting antibody to the cytotoxic payload. The selection of an appropriate linker is paramount for ensuring the stability of the conjugate in the bloodstream and its efficient release within the tumor microenvironment. For researchers exploring advanced drug delivery systems and novel cancer treatments, sourcing high-quality linkers is a critical step. They often search for 'N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide supplier China' to find reliable sources.
N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide (CAS 159857-80-4), often referred to as MC-Val-Cit-PAB, is a highly specialized peptide linker. Its design incorporates a valine-citrulline dipeptide sequence, which is recognized and cleaved by intracellular enzymes such as Cathepsin B. This enzymatic cleavage capability is vital for the controlled release of the drug payload directly within cancer cells. This specificity makes it an ideal component for researchers looking to buy pharmaceutical intermediates that enhance drug delivery and therapeutic outcomes.
NINGBO INNO PHARMCHEM CO.,LTD., as a leading manufacturer in China, specializes in producing high-purity pharmaceutical intermediates, including advanced linkers like MC-Val-Cit-PAB. Their commitment to quality ensures that researchers have access to reliable materials for their ADC development programs. The ability to purchase these complex molecules allows for the creation of more potent and safer cancer therapies. The ongoing research into peptide linkers continues to push the boundaries of targeted drug delivery, making compounds like N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide indispensable tools in the fight against cancer.
N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide (CAS 159857-80-4), often referred to as MC-Val-Cit-PAB, is a highly specialized peptide linker. Its design incorporates a valine-citrulline dipeptide sequence, which is recognized and cleaved by intracellular enzymes such as Cathepsin B. This enzymatic cleavage capability is vital for the controlled release of the drug payload directly within cancer cells. This specificity makes it an ideal component for researchers looking to buy pharmaceutical intermediates that enhance drug delivery and therapeutic outcomes.
NINGBO INNO PHARMCHEM CO.,LTD., as a leading manufacturer in China, specializes in producing high-purity pharmaceutical intermediates, including advanced linkers like MC-Val-Cit-PAB. Their commitment to quality ensures that researchers have access to reliable materials for their ADC development programs. The ability to purchase these complex molecules allows for the creation of more potent and safer cancer therapies. The ongoing research into peptide linkers continues to push the boundaries of targeted drug delivery, making compounds like N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide indispensable tools in the fight against cancer.
Perspectives & Insights
Nano Explorer 01
“For researchers exploring advanced drug delivery systems and novel cancer treatments, sourcing high-quality linkers is a critical step.”
Data Catalyst One
“They often search for 'N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide supplier China' to find reliable sources.”
Chem Thinker Labs
“N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide (CAS 159857-80-4), often referred to as MC-Val-Cit-PAB, is a highly specialized peptide linker.”