In the realm of pharmaceutical development, understanding how a drug is absorbed, distributed, metabolized, and excreted (ADME) is as crucial as its therapeutic efficacy. Metabolites, the products of drug metabolism, provide invaluable insights into these processes. 1-(2-Pyrimidinyl)piperazine (CAS 20980-22-7) is a prime example of a metabolite that plays a significant role in pharmacokinetic (PK) studies, offering a deeper understanding of drug behavior in the body. As a dedicated pharmaceutical intermediate and metabolite supplier, we highlight its importance.

1-(2-Pyrimidinyl)piperazine: A Key Metabolite and Its Significance

1-(2-Pyrimidinyl)piperazine is notably identified as a major metabolite of Tandospirone, an anxiolytic drug. During drug metabolism, the parent drug undergoes enzymatic transformations within the body, yielding various metabolites. Some metabolites can be pharmacologically active, contributing to the overall therapeutic effect or side effects, while others may be inactive. In the case of Tandospirone, 1-(2-Pyrimidinyl)piperazine has been shown to possess pharmacological activity, making it a substance of interest in its own right.

The study of such metabolites is fundamental to PK analysis. Pharmacokinetics describes 'what the body does to the drug'. By tracking the concentrations of both the parent drug and its active metabolites over time in biological fluids (like plasma or urine), researchers can:

  • Assess Drug Bioavailability: Understand how much of the administered drug reaches systemic circulation and in what form.
  • Determine Elimination Half-Life: Calculate the time it takes for the drug and its metabolites to be eliminated from the body.
  • Identify Potential Drug-Drug Interactions: Understand how other medications might affect the metabolism and clearance of the drug and its metabolites.
  • Investigate Efficacy and Toxicity: Determine if active metabolites contribute significantly to the drug's therapeutic effects or potential adverse reactions.
  • Develop Bioanalytical Methods: Establish methods for accurately quantifying the drug and its metabolites in biological samples, which is essential for clinical trials and therapeutic drug monitoring.

For researchers in drug metabolism and pharmacokinetics, having access to high-purity 1-(2-Pyrimidinyl)piperazine is essential for accurate analytical method development and validation. It is used as a reference standard to identify and quantify its presence in biological matrices.

Sourcing Quality Metabolites for Research

As a trusted pharmaceutical intermediate supplier, we understand the critical need for high-quality reference standards. When you buy 1-(2-Pyrimidinyl)piperazine from us, you are obtaining a compound manufactured under strict quality controls, ensuring its suitability for sensitive PK studies. Our commitment to providing materials with well-defined specifications, including purity and CAS 20980-22-7, supports reliable research outcomes.

The ability to source such specialized compounds from reliable manufacturers in China enables research institutions and pharmaceutical companies worldwide to advance their drug development programs. By providing the tools necessary for comprehensive ADME and PK profiling, we contribute to the safer and more effective development of new medicines.

If your research involves Tandospirone or requires a reliable standard for pharmacokinetic studies, 1-(2-Pyrimidinyl)piperazine is a compound of significant importance. We invite you to explore our offerings and discover how our commitment to quality and supply chain excellence can support your critical research needs.