Methotrexate (CAS 59-05-2) is a fundamental compound in pharmaceutical manufacturing, recognized for its critical roles in chemotherapy and as an immunosuppressant for autoimmune conditions. For professionals in the pharmaceutical sector, understanding the detailed specifications and sourcing reliable manufacturers is paramount. This article provides an overview of Methotrexate's key properties and guidance for buyers looking to procure this essential pharmaceutical intermediate, particularly from China-based suppliers.

The chemical identity of Methotrexate is well-defined by its CAS number, 59-05-2, and its molecular formula, C20H22N8O5. Physically, it presents as an orange-yellow crystalline powder, a characteristic that aids in its identification. Its stability is notable, though it is sensitive to light and hygroscopic, requiring specific storage conditions, typically at temperatures of -15°C or below, to maintain its integrity and efficacy. These properties are critical for manufacturers and formulators to consider during handling, storage, and integration into pharmaceutical products.

The therapeutic significance of Methotrexate stems from its action as a folate antagonist and a dihydrofolate reductase inhibitor. This mechanism makes it highly effective in cancer treatment by interfering with DNA synthesis and cell replication. Beyond oncology, it serves as a vital agent in managing autoimmune diseases, including psoriasis and rheumatoid arthritis, by regulating immune system responses and reducing inflammation. Its versatility as a pharmaceutical intermediate makes it a sought-after compound for a wide range of drug developments.

For businesses seeking to buy Methotrexate, identifying a dependable manufacturer is a crucial step. China has emerged as a significant hub for chemical manufacturing, offering competitive pricing and substantial production capacities. When sourcing, it is advisable to look for manufacturers that can guarantee a high purity level, typically 99% or above, and provide comprehensive documentation such as Certificates of Analysis (CoA). Direct inquiry to manufacturers for pricing, minimum order quantities (MOQ), and delivery timelines is recommended to establish a clear understanding of the supply terms.

Key considerations for buyers include the supplier's adherence to quality standards, their manufacturing capacity, and their ability to ensure a consistent supply chain. Companies specializing in pharmaceutical intermediates are well-equipped to meet the stringent demands of the pharmaceutical industry. Exploring partnerships with established China-based manufacturers for Methotrexate can provide a strategic advantage in securing a critical raw material that is essential for producing vital medications.

In essence, Methotrexate is more than just a chemical compound; it is a critical element in numerous therapeutic regimens. By understanding its properties and engaging with reputable manufacturers, pharmaceutical companies can ensure they are obtaining a high-quality intermediate that meets all necessary specifications, thereby supporting the development and availability of important medicines.