For chemical manufacturers and product formulators, understanding the properties and synthesis of key intermediates is fundamental to developing and producing new materials. Methyl 2-(2-amino-1,3-thiazol-4-yl)acetate (CAS 64987-16-2) is a significant compound with applications in pharmaceuticals and fine chemicals. This article explores its characteristics and synthesis, providing valuable insights for industry professionals.

Key Chemical Properties and Specifications

Methyl 2-(2-amino-1,3-thiazol-4-yl)acetate is characterized by its molecular formula C6H8N2O2S and a molecular weight of 172.20. It presents as a white to beige solid, with a melting point typically ranging from 112-116°C. Its other physical properties, such as boiling point (307.3°C) and flash point (139.7°C), are important considerations for handling and processing. For manufacturers, a key specification is its purity, commonly offered at ≥99.0%. This high purity ensures that the compound performs reliably in subsequent synthesis steps, whether it's for pharmaceutical applications like cefotiam or for other fine chemical products. Manufacturers looking to purchase this material often search for “methyl 2-amino-4-thiazoleacetate specification” or “high purity CAS 64987-16-2”.

Synthesis Pathways for Methyl 2-(2-amino-1,3-thiazol-4-yl)acetate

The synthesis of Methyl 2-(2-amino-1,3-thiazol-4-yl)acetate often involves the esterification of 2-amino-4-thiazoleacetic acid with methanol in the presence of an acid catalyst, such as sulfuric acid. This reaction requires careful control of temperature and reaction time to achieve optimal yields and purity. For manufacturers aiming to produce this intermediate efficiently, understanding these synthesis parameters is crucial. Information regarding “how to synthesize methyl 2-amino-4-thiazoleacetate” is vital for process optimization and scaling up production. Partnering with experienced suppliers who have mastered these synthesis routes can ensure a consistent and high-quality supply chain.

Applications and Market Relevance

The primary market driver for Methyl 2-(2-amino-1,3-thiazol-4-yl)acetate is its role as an intermediate in the synthesis of cefotiam, a crucial antibiotic. However, its versatile chemical structure also makes it a valuable building block for other fine chemicals and potentially for novel pharmaceutical candidates. Chemical manufacturers who supply this compound can tap into a steady demand from the pharmaceutical sector. For those looking to buy this intermediate, searching for “pharmaceutical intermediate manufacturer” or “specialty chemical supplier” will lead to reliable sources, often in China, offering competitive pricing and bulk quantities.

In essence, Methyl 2-(2-amino-1,3-thiazol-4-yl)acetate is a critical fine chemical intermediate. By understanding its properties, synthesis, and market applications, chemical manufacturers can effectively integrate it into their product portfolios or supply chains, ensuring both quality and cost-effectiveness.