Methyl 4-Benzyloxy-3-methoxybenzoate: Properties and Synthesis for Chemical Professionals
Methyl 4-Benzyloxy-3-methoxybenzoate (CAS: 56441-97-5) is a compound of significant interest in the field of organic chemistry and pharmaceutical manufacturing. Its unique structural features, including a methyl ester, a benzyloxy ether, and a methoxy group on an aromatic core, confer specific reactivity that makes it a valuable intermediate. For chemical professionals seeking to 'buy methyl 4-benzyloxy-3-methoxybenzoate,' understanding its properties and synthesis pathways is key to successful application.
Physically, this compound typically presents as an off-white solid, with a reported purity of around 97%. Its solubility in common organic solvents such as dichloromethane (DCM) and ethyl acetate facilitates its use in various reaction media. The boiling point, though high at around 400°C, indicates its relative thermal stability under typical laboratory and industrial processing conditions. When considering a 'methyl 4-benzyloxy-3-methoxybenzoate supplier China' that provides this material, verified purity and detailed technical specifications are essential.
The synthesis of Methyl 4-Benzyloxy-3-methoxybenzoate often begins with methyl vanillate. A common synthetic route involves the benzylation of the phenolic hydroxyl group of methyl vanillate using benzyl bromide in the presence of a base like potassium carbonate. This reaction, typically conducted in a solvent such as dimethylformamide (DMF) and heated to around 100°C, yields the target compound. The process requires careful control of reaction conditions to ensure high yield and purity, minimizing the formation of unwanted byproducts. This highlights why partnering with an experienced 'pharmaceutical intermediate manufacturer 56441-97-5' is beneficial.
Beyond its primary use as an intermediate for drugs like Clomiphene, Methyl 4-Benzyloxy-3-methoxybenzoate serves as a versatile building block in broader 'custom synthesis for drug discovery' projects. Its aromatic system can undergo electrophilic aromatic substitution, and the ester group can be hydrolyzed or transesterified, offering further avenues for chemical modification. For those looking for 'high purity C16H16O4 for sale,' engaging with a manufacturer that can also provide custom synthesis services can be advantageous for developing novel compounds.
The 'methyl 4-benzyloxy-3-methoxybenzoate price' can vary depending on the supplier, quantity, and purity. However, the consistent quality and reliable supply from established Chinese manufacturers make them a preferred choice for many global clients. We pride ourselves on being a leading provider of such specialized chemicals, ensuring our clients receive materials that meet their exacting research and manufacturing needs.
Perspectives & Insights
Alpha Spark Labs
“A common synthetic route involves the benzylation of the phenolic hydroxyl group of methyl vanillate using benzyl bromide in the presence of a base like potassium carbonate.”
Future Pioneer 88
“This reaction, typically conducted in a solvent such as dimethylformamide (DMF) and heated to around 100°C, yields the target compound.”
Core Explorer Pro
“The process requires careful control of reaction conditions to ensure high yield and purity, minimizing the formation of unwanted byproducts.”