For professionals in the chemical and pharmaceutical industries, a deep understanding of the synthesis pathways and chemical properties of key intermediates is fundamental to their effective utilization. Methyl 4-chloropicolinate (CAS 24484-93-3) is one such compound, valued for its reactivity and application in various synthesis projects. This overview details its common preparation methods and its significant chemical characteristics.

The synthesis of Methyl 4-chloropicolinate typically begins with 2-picolinic acid. A common industrial route involves converting 2-picolinic acid into its corresponding acyl chloride using reagents like thionyl chloride (SOCl2), often in the presence of a catalyst such as DMF. Following the formation of the acyl chloride, esterification with methanol (MeOH) yields the desired Methyl 4-chloropicolinate. This process is optimized by manufacturers to achieve high purity, often exceeding 98%, which is critical for its use in demanding applications. NINGBO INNO PHARMCHEM CO.,LTD., as a prominent manufacturer and supplier in China, employs refined synthesis techniques to ensure product quality and consistency.

Chemically, Methyl 4-chloropicolinate possesses a molecular formula of C7H6ClNO2 and a molecular weight of 171.58 g/mol. It typically appears as a white crystalline powder, with a melting point ranging from 50-52°C. Its structure, featuring a pyridine ring with a chlorine substituent and a methyl ester, dictates its reactivity. The chlorine atom at the 4-position is labile and can readily undergo nucleophilic aromatic substitution reactions, making it an excellent intermediate for introducing diverse functional groups. The ester group can also be manipulated through various reactions, including hydrolysis or reduction. This versatility makes it a sought-after building block for custom synthesis and the development of novel compounds.

Researchers and procurement managers looking to buy Methyl 4-chloropicolinate will find that understanding these synthesis details and chemical properties helps in selecting the most suitable supplier. When you purchase from a dedicated manufacturer like NINGBO INNO PHARMCHEM CO.,LTD., you gain access to not only a high-purity product but also valuable technical insights that can aid in your synthetic endeavors. We encourage all interested parties to inquire about our product and its potential applications.