In the realm of chemical synthesis, certain intermediates stand out for their versatility and broad applicability. Methyl 6-Bromopicolinate, identified by CAS number 26218-75-7, is one such compound. This brominated pyridine derivative is a valuable tool for chemists in both academic research and industrial production, particularly in the pharmaceutical and agrochemical sectors. Understanding its synthesis applications and knowing where to reliably buy this chemical is essential for researchers and manufacturers aiming for efficiency and quality in their projects.

Key Synthesis Applications of Methyl 6-Bromopicolinate

Methyl 6-Bromopicolinate serves as a fundamental building block due to the reactivity of its constituent functional groups:

  • Cross-Coupling Reactions: The bromine atom at the 6-position is highly amenable to various palladium-catalyzed cross-coupling reactions. These include Suzuki-Miyaura coupling (with boronic acids), Stille coupling (with organostannanes), and Sonogashira coupling (with terminal alkynes). These reactions allow for the efficient introduction of carbon-carbon bonds, enabling the construction of complex heterocyclic frameworks. These are critical steps in the synthesis of many pharmaceuticals.
  • Nucleophilic Aromatic Substitution: The bromine can also be displaced by various nucleophiles under appropriate conditions, providing routes to introduce nitrogen, oxygen, or sulfur-containing substituents onto the pyridine ring.
  • Ester Modification: The methyl ester group can be readily hydrolyzed to the carboxylic acid, which can then be further derivatized into amides, other esters, or reduced to an alcohol. This flexibility allows for diverse downstream modifications of the molecule.
  • Pharmaceutical Intermediate: Its structure is a common feature in many biologically active molecules, making it a sought-after intermediate for drug discovery and development. It is frequently used in the synthesis of agents targeting various diseases.
  • Agrochemical Intermediate: Similar to pharmaceuticals, many herbicides, insecticides, and fungicides incorporate pyridine rings, making Methyl 6-Bromopicolinate a useful precursor in this field as well.

Where to Buy Methyl 6-Bromopicolinate

For those looking to purchase Methyl 6-Bromopicolinate, particularly with high purity (e.g., ≥99%), sourcing from reputable chemical manufacturers is key. China is a major global supplier of such intermediates, offering competitive pricing and significant production capacity. When you need to buy Methyl 6-Bromopicolinate, consider the following:

  1. Identify Manufacturers with Strong Quality Control: Look for suppliers who consistently provide high-purity products and reliable Certificates of Analysis (CoA).
  2. Compare Pricing and MOQs: Obtain multiple quotes to secure the best value for your required quantities. Understand their Minimum Order Quantities (MOQs).
  3. Assess Supplier Reliability: Check for established companies with good customer reviews and a stable supply chain.
  4. Request Samples: Before placing large orders, it is advisable to obtain samples for your internal quality checks and synthesis trials.

By focusing on these aspects, researchers and manufacturers can confidently source Methyl 6-Bromopicolinate (CAS 26218-75-7), ensuring the quality and efficiency of their chemical synthesis projects.