For organic chemists engaged in the synthesis of complex molecules, understanding the properties and availability of key building blocks is fundamental. Methyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate (CAS 1062368-70-0) is a significant heterocyclic intermediate that offers considerable synthetic utility. This article serves as a guide for chemists looking to acquire this compound, detailing its chemical characteristics and providing insights on how to find reliable manufacturers and suppliers to purchase it efficiently.

The pyrazolo[1,5-a]pyridine nucleus is a core structure found in many compounds with interesting chemical and biological properties. The specific substitution pattern of Methyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate, featuring a bromine atom at the C-6 position and a methyl ester at C-3, makes it a highly versatile synthon. The bromine atom is an excellent leaving group for palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Heck, and Sonogashira couplings, allowing for the introduction of aryl, alkenyl, or alkynyl groups. The methyl ester can be readily hydrolyzed to the corresponding carboxylic acid, which can then be converted into amides, esters, or other derivatives, further expanding the synthetic possibilities.

The synthesis of Methyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate typically involves multi-step organic transformations starting from simpler precursors. While specific proprietary synthesis routes may vary among manufacturers, they often involve cyclization reactions to form the bicyclic core, followed by regioselective bromination and esterification. Understanding these synthetic pathways can help chemists appreciate the value and complexity involved in producing this intermediate at scale.

When chemists need to procure Methyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate for their research or production, identifying a dependable supplier is crucial. Many chemical manufacturers and distributors worldwide offer this compound. However, for cost-effectiveness and reliable bulk supply, many turn to manufacturers based in China. Companies that specialize in fine chemicals and pharmaceutical intermediates often list this compound, providing detailed specifications, safety data sheets (SDS), and pricing information. It is advisable to compare offers from multiple suppliers to secure the best price and quality for your intended application.

To effectively buy Methyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate, chemists should clearly define their purity requirements, desired quantities, and delivery timelines. Requesting a quote from potential manufacturers will facilitate this process. By leveraging online chemical databases and supplier directories, chemists can quickly identify and engage with those offering this valuable building block, thereby accelerating their synthesis projects and driving innovation in chemical research.