The pharmaceutical industry relies heavily on a precise and dependable supply of chemical intermediates. Among these, Methyl 6-Methylnicotinate (CAS: 5470-70-2) stands out as a crucial compound, pivotal in the synthesis of vital active pharmaceutical ingredients (APIs) and in the broader field of drug discovery. Understanding its chemical profile, applications, and sourcing options is essential for R&D scientists, medicinal chemists, and procurement specialists.

Methyl 6-Methylnicotinate is a pyridine derivative, characterized by its specific chemical structure and properties. Its primary claim to fame is its indispensable role as an intermediate in the synthesis of Etoricoxib, a selective cyclooxygenase-2 (COX-2) inhibitor. This makes it a highly sought-after raw material for pharmaceutical manufacturers producing this important anti-inflammatory drug. The demand for high-purity Methyl 6-Methylnicotinate is thus directly linked to the global market for Etoricoxib.

Beyond its direct application in Etoricoxib production, Methyl 6-Methylnicotinate is a valuable building block in organic synthesis. Its heterocyclic nature offers a versatile platform for chemists to develop novel compounds with potential therapeutic applications. Researchers in drug discovery often look for such intermediates to explore new chemical entities, aiming to create next-generation pharmaceuticals with improved efficacy or targeted action. This broad applicability underscores its importance in the advancement of medicinal chemistry.

For those in the industry looking to buy Methyl 6-Methylnicotinate, understanding its specifications is crucial. Typically available as a light yellow liquid or solid, it boasts a high assay, often exceeding 97.0%. This high purity is paramount for pharmaceutical applications to avoid impurities that could compromise the final API or introduce unwanted side effects. When sourcing, it's advisable to inquire about the product's CAS number (5470-70-2) and the purity levels offered by the supplier.

The global supply chain for pharmaceutical intermediates is robust, with many reliable manufacturers located in China. These manufacturers are adept at producing Methyl 6-Methylnicotinate to exacting standards, offering competitive pricing and consistent availability. For companies requiring bulk quantities, partnering with a reputable supplier that can ensure timely delivery and excellent customer service is vital for maintaining production schedules and controlling costs. Exploring options for purchasing this intermediate involves researching suppliers and obtaining quotations.

In summary, Methyl 6-Methylnicotinate is a cornerstone intermediate for both established API manufacturing and cutting-edge drug discovery. Its critical function in Etoricoxib synthesis and its potential as a versatile building block make it an essential component in the pharmaceutical R&D toolkit. By focusing on purity, reliability, and strategic sourcing from experienced manufacturers, the industry can continue to innovate and deliver life-changing medicines.