Miconazole (CAS 22916-47-8) is a chemical compound of significant interest in the pharmaceutical and chemical industries due to its potent antifungal properties. Understanding its chemical structure, properties, and diverse applications is crucial for researchers, developers, and manufacturers seeking to leverage its capabilities. This article provides an in-depth look at Miconazole, offering insights into its chemical nature and its wide-ranging uses.

Chemical Profile of Miconazole

Miconazole is an imidazole derivative with the chemical name 1H-Imidazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-. Its molecular formula is C18H14Cl4N2O, and it has a molecular weight of approximately 416.13 g/mol.

Key chemical properties include:

  • Appearance: Typically appears as a white to off-white crystalline powder.
  • Solubility: It is very slightly soluble in water but freely soluble in alcohols, methanol, and acetone, and soluble in ethanol (96 percent). It is also soluble in DMF or chloroform.
  • Melting Point: The melting point generally falls between 159-163°C, though variations can occur based on purity and crystalline form.
  • Mechanism of Action: Miconazole inhibits the synthesis of ergosterol, a critical component of fungal cell membranes. By blocking the enzyme lanosterol 14α-demethylase, it disrupts membrane integrity and function, leading to fungal cell death or inhibition.

Diverse Applications of Miconazole

The antifungal efficacy of Miconazole makes it invaluable across several sectors:

  • Pharmaceuticals: It serves as an active pharmaceutical ingredient (API) in a wide array of topical treatments for skin infections caused by dermatophytes and yeasts, such as athlete's foot, ringworm, and jock itch. It is also formulated into vaginal creams and oral gels to treat candidiasis.
  • Veterinary Medicine: Miconazole is employed in veterinary products to treat fungal infections in animals, often in topical formulations for skin and ear conditions.
  • Cosmetics: In cosmetic applications, it can be used in products designed to manage fungal issues on the skin or to enhance product preservation.
  • Research: As a well-characterized antifungal compound, Miconazole is frequently used in laboratory research to study fungal biology, drug resistance mechanisms, and to screen for new antifungal agents. Researchers often buy Miconazole for its reliable antifungal activity.

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