Monomethyl 5-nitroisophthalate, identified by CAS 1955-46-0, is a functionalized aromatic compound that serves as a critical intermediate in various chemical industries. Understanding its properties, synthesis, and market dynamics is essential for procurement professionals and research scientists seeking to optimize their supply chains and product development strategies. As a manufacturer and supplier, we provide detailed information on this compound to facilitate informed decision-making.

The chemical structure of Monomethyl 5-nitroisophthalate is characterized by a benzene ring with a methyl ester group at position 1, a carboxylic acid group at position 3, and a nitro group at position 5. This unique arrangement of functional groups imparts specific reactivity, making it a valuable starting material for organic synthesis. Its molecular weight is approximately 225.16 g/mol, and it typically appears as a slightly yellow fine crystalline powder. Solubility in water is limited, but it is soluble in many organic solvents, a characteristic that influences its handling and reaction conditions.

The synthesis of Monomethyl 5-nitroisophthalate typically involves the selective mono-esterification of 5-nitroisophthalic acid with methanol. This process can be carried out using various acidic catalysts. Achieving high purity often requires careful control of reaction parameters, such as temperature, reaction time, and molar ratios of reactants, followed by appropriate purification techniques like recrystallization. The efficiency and yield of the synthesis are critical factors for cost-effective production, especially when serving the pharmaceutical intermediate market where purity is paramount.

The applications of Monomethyl 5-nitroisophthalate are diverse, primarily revolving around its role as a chemical intermediate. In the pharmaceutical industry, it is a key precursor for synthesizing certain APIs, including LSD1 inhibitors for cancer therapy and components for X-ray contrast media. Its utility also extends to bioconjugation, where it is used to create crosslinking agents for linking biomolecules, and in materials science, as a monomer for polyester resins used in specialized coatings. These applications highlight its importance across multiple high-value sectors.

From a market perspective, the demand for Monomethyl 5-nitroisophthalate is closely tied to the growth of the pharmaceutical and fine chemical industries. Factors such as increasing R&D investments in oncology and diagnostic imaging, coupled with advancements in materials science, contribute to a steady demand for this intermediate. Procurement professionals should focus on identifying reliable manufacturers and suppliers, particularly those in Asia, who can offer competitive pricing along with guaranteed high purity and consistent supply. Establishing robust relationships with suppliers who understand the stringent quality requirements of these industries is key to ensuring a stable and efficient supply chain for Monomethyl 5-nitroisophthalate.