In the dynamic field of drug discovery, access to high-quality chemical intermediates is not just a requirement, but a strategic advantage. N-(4-Chlorophenyl)-2-nitrobenzenamine, identified by CAS number 23008-56-2, stands out as a pivotal compound, particularly for researchers focusing on oncology and infectious diseases. This article delves into the significance of this intermediate, its applications in creating potent c-Met kinase inhibitors, and how to effectively procure it from leading manufacturers and suppliers globally.

The Role of N-(4-Chlorophenyl)-2-nitrobenzenamine in Modern Synthesis

N-(4-Chlorophenyl)-2-nitrobenzenamine (C12H9ClN2O2) is a versatile organic building block. Its chemical structure, featuring a nitro group and a substituted phenylamine, makes it an ideal starting material for synthesizing complex molecules. Its most notable application is in the development of novel 4-phenoxyquinoline derivatives that act as potent c-Met kinase inhibitors. The c-Met pathway is frequently implicated in tumor growth, metastasis, and drug resistance, making inhibitors of this pathway a significant area of research in cancer therapeutics. By utilizing N-(4-Chlorophenyl)-2-nitrobenzenamine, researchers can efficiently construct these targeted molecules.

Furthermore, this compound plays a role as an intermediate in the synthesis of Clofazimine, a crucial medicine for treating multidrug-resistant tuberculosis and leprosy. The availability of a reliable and pure source of N-(4-Chlorophenyl)-2-nitrobenzenamine is therefore critical for both cutting-edge research and the production of essential medicines.

Procurement Strategies: Finding the Right Manufacturer

For scientists and procurement specialists, finding a dependable supplier for N-(4-Chlorophenyl)-2-nitrobenzenamine is key. When searching for this intermediate, consider the following:

  • Supplier Specialization: Look for manufacturers or suppliers that specialize in pharmaceutical intermediates and fine chemicals. Their expertise ensures a higher likelihood of consistent quality and product integrity.
  • Purity Levels: Confirm that the product meets the required purity specifications, typically above 98%. Always request a Certificate of Analysis (CoA) with each batch.
  • Batch-to-Batch Consistency: For ongoing research or manufacturing, ensuring consistency across different batches is vital. Inquire about the supplier's quality control processes.
  • Pricing and Quotes: Obtain multiple quotes to compare pricing, especially for bulk orders. Suppliers based in China often offer competitive pricing structures.
  • Technical Support: A good supplier will offer technical support, including safety data sheets (SDS) and potentially application-specific advice.

Ensuring Quality and Accessibility

The chemical industry relies on the seamless availability of high-purity intermediates like N-(4-Chlorophenyl)-2-nitrobenzenamine. Whether your focus is on pioneering oncology drugs or ensuring the supply of established treatments, a robust procurement strategy is essential. By partnering with experienced manufacturers, you can guarantee the quality and availability of this critical compound, thereby accelerating your research and development timelines and contributing to advancements in healthcare. We are dedicated to being your trusted partner, providing high-quality N-(4-Chlorophenyl)-2-nitrobenzenamine to fuel your scientific endeavors.