Organic synthesis is the bedrock of many modern industries, from pharmaceuticals and agrochemicals to advanced materials. Within this complex field, specific chemical intermediates are indispensable for building intricate molecular structures. N-Ethylmaleimide (CAS 128-53-0) is one such versatile compound, prized for its reactivity and utility in a variety of synthetic pathways. As a leading specialty chemical manufacturer and supplier in China, we are dedicated to providing high-purity N-Ethylmaleimide to researchers and industrial chemists worldwide. This article highlights the key applications of N-Ethylmaleimide in organic synthesis and guides procurement specialists on how to source this essential material.

The maleimide functional group within N-Ethylmaleimide is a powerful electrophile, readily undergoing addition reactions with nucleophiles. This characteristic makes it a valuable component in numerous synthetic transformations:

  • Diels-Alder Reactions: The double bond in the maleimide ring can participate in [4+2] cycloaddition reactions, commonly known as Diels-Alder reactions. These reactions are fundamental for constructing cyclic systems, which are prevalent in natural products and pharmaceuticals. N-Ethylmaleimide acts as a reactive dienophile, enabling the synthesis of complex polycyclic frameworks.
  • Michael Additions: As previously discussed in the context of protein crosslinking, N-Ethylmaleimide readily undergoes Michael addition with various nucleophiles, including thiols, amines, and carbanions. This reaction is a versatile tool for carbon-carbon and carbon-heteroatom bond formation, allowing for the introduction of functional groups and the extension of carbon chains.
  • Synthesis of Heterocycles: The structure of N-Ethylmaleimide lends itself to the synthesis of various nitrogen-containing heterocycles, which are important structural motifs in many biologically active compounds. Through carefully designed reaction sequences, the maleimide core can be transformed into a range of complex heterocyclic systems.
  • Polymerization Monomer: N-Ethylmaleimide can also serve as a monomer or co-monomer in the synthesis of specialty polymers. Its incorporation into polymer chains can impart unique properties such as thermal stability or specific chemical reactivity.

For R&D scientists and procurement managers looking to purchase N-Ethylmaleimide, consistency and purity are paramount. Our commitment as a manufacturer in China ensures that we supply N-Ethylmaleimide with a guaranteed purity of 98% HPLC. This high level of purity is critical for achieving reproducible results in organic synthesis and minimizing the formation of unwanted byproducts. We encourage you to request a quote to explore our competitive pricing and discuss your specific quantity requirements.

Sourcing directly from a reputable Chinese manufacturer offers distinct advantages, including cost-effectiveness and a reliable supply chain. We understand that timely delivery of raw materials is crucial for maintaining project timelines and operational efficiency. Our robust logistics network ensures that N-Ethylmaleimide reaches your facility efficiently.

In conclusion, N-Ethylmaleimide (CAS 128-53-0) is a highly valuable intermediate in organic synthesis, enabling key reactions like Diels-Alder cycloadditions and Michael additions for the construction of complex molecules. As a trusted supplier, we provide high-purity material backed by strong manufacturing capabilities. Make N-Ethylmaleimide a staple in your synthetic chemistry toolkit by sourcing from a dependable Chinese manufacturer and supplier.