For scientists engaged in pharmaceutical research and development, particularly in the field of oncology, understanding the precise technical specifications of chemical intermediates is crucial for experimental success. N-Pyridin-2-yl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide, bearing the CAS number 1383385-64-5, is a key intermediate in the synthesis of Acalabrutinib. This article aims to provide R&D professionals and procurement managers with detailed technical information about this compound, highlighting why selecting a reputable supplier is vital.

Chemical Identity and Properties

The chemical structure of N-Pyridin-2-yl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide is C18H21BN2O3, with a molecular weight of approximately 324.18 g/mol. Its common synonyms include N-2-Pyridinyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide and Acalabrutinib Intermediate 2. The typical appearance described is a white to off-white solid, a critical visual indicator of purity. The predicted boiling point is around 414.1±25.0 °C, and its density is approximately 1.16±0.1 g/cm³.

Quality Standards for Procurement

When sourcing this intermediate, paying close attention to the following technical aspects from your supplier is essential:

  • Purity Level: Most applications, especially in API synthesis, require a purity of >98%. Lower purity levels can lead to incomplete reactions, formation of unwanted by-products, and challenges in downstream purification.
  • Storage Conditions: The compound is typically recommended to be stored at 2-8°C to maintain its stability and prevent degradation. Suppliers should confirm adherence to these storage requirements during shipping and handling.
  • Analytical Data: Availability of a comprehensive Certificate of Analysis (CoA) detailing purity, spectroscopic data (e.g., NMR, Mass Spectrometry), and impurity profiles is a strong indicator of a reliable manufacturer.
  • Packaging: Appropriate packaging, such as bottles or barrels, designed to protect the chemical from moisture and contamination during transit is crucial.

The Advantage of Sourcing from an Experienced Manufacturer

As a dedicated manufacturer of pharmaceutical intermediates, our company ensures that N-Pyridin-2-yl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide meets stringent technical specifications. We understand the critical role this compound plays in the successful synthesis of Acalabrutinib. Our commitment to quality means that when you buy from us, you receive a product characterized by its high purity and consistent performance. We offer detailed technical documentation and support to aid your research and development efforts. Contact us today to obtain a quotation and to discuss how our reliable supply of this key intermediate can benefit your scientific endeavors.