The pharmaceutical research and development (R&D) landscape thrives on access to precise and high-quality chemical building blocks. N-tert-Butylglycine Hydrochloride (CAS 6939-23-7) is one such compound that plays a significant role in drug discovery and synthesis. For researchers and chemists in the pharmaceutical industry, understanding its detailed specifications and potential applications is crucial for successful project outcomes. This article provides an overview of N-tert-Butylglycine Hydrochloride, focusing on its properties and how it serves the R&D community, emphasizing the importance of sourcing from a dependable manufacturer.

Understanding the Compound: N-tert-Butylglycine Hydrochloride

N-tert-Butylglycine Hydrochloride is a white powder characterized by its specific chemical structure and properties. Its CAS number, 6939-23-7, uniquely identifies it within the global chemical database. With a molecular formula of C6H14ClNO2 and a molecular weight of 167.63, it presents itself as a stable organic compound. While its most prominent application is as an intermediate in the synthesis of the antibiotic Tigecycline, its utility extends to various R&D initiatives within the pharmaceutical sector. Researchers often look for this compound when exploring new synthetic routes or developing novel molecules that require its specific functional groups.

Detailed Specifications for Research Purity

For R&D purposes, the purity and consistency of chemical reagents are paramount. N-tert-Butylglycine Hydrochloride is generally supplied with a purity of ≥99%, often confirmed via High-Performance Liquid Chromatography (HPLC). Critical quality parameters that researchers and procurement specialists look for include:

  • Appearance: Typically described as a white powder or crystalline solid.
  • Purity (HPLC): ≥99.0% is a common benchmark.
  • Largest Single Impurity: Usually specified as ≤0.5%.
  • Total Impurities: Ideally kept below 1.0%.
  • Moisture Content (Loss on Drying): Low levels, often ≤1.0%, are preferred to ensure stability.
  • Specific Ion Limits: Controlled levels of chloride (≤0.020%), ammonium (≤0.02%), and sulfate (≤0.020%) are important for many reactions.
  • Heavy Metals & Trace Elements: Strict limits on iron (≤10 ppm), lead (≤10 ppm), and arsenic (≤1 ppm) are typically required.
  • Chromatographic Purity: The absence of other amino acids is a significant indicator of high quality for specialized synthesis.

Sourcing this compound from a reputable chemical supplier or manufacturer in China guarantees access to detailed Certificates of Analysis (CoA) that validate these specifications, enabling researchers to proceed with confidence.

Applications in Pharmaceutical R&D

The primary driver for R&D interest in N-tert-Butylglycine Hydrochloride is its role in synthetic organic chemistry, particularly in the pharmaceutical industry:

  1. Antibiotic Synthesis: As mentioned, it is a crucial intermediate for Tigecycline. R&D efforts may focus on optimizing the synthesis pathway, improving yields, or developing related glycylcycline antibiotics.
  2. Peptide Chemistry: As a glycine derivative, it can be explored for incorporation into modified peptides or peptidomimetics, potentially for therapeutic applications or as research tools.
  3. Building Block for Novel APIs: The tert-butylamino and carboxylic acid functionalities, coupled with the hydrochloride salt, make it a versatile building block for synthesizing a wide array of novel chemical entities (NCEs) with potential biological activity.
  4. Process Development: Researchers developing new chemical processes might use it as a model compound or reagent to test reaction conditions, catalysts, or purification techniques.

When purchasing N-tert-Butylglycine Hydrochloride for research, consider the quantity needed, as suppliers often offer various pack sizes suitable for laboratory work. Engaging with a supplier that also provides technical support can be invaluable for complex research projects.

Procurement Best Practices for Researchers

For researchers and procurement officers in R&D settings, best practices for buying N-tert-Butylglycine Hydrochloride include:

  • Clarify Purity Needs: Determine if standard industrial purity suffices or if an even higher purity grade is required for specific sensitive reactions.
  • Supplier Verification: Choose suppliers known for reliability and quality. China-based manufacturers often offer a good balance of quality and price.
  • Request Samples: For initial R&D projects, requesting samples can be a good way to evaluate the material before committing to larger purchases.
  • Technical Data Sheets: Always ask for comprehensive technical data sheets and safety data sheets (SDS).

By adhering to these practices, R&D professionals can efficiently source the necessary N-tert-Butylglycine Hydrochloride to advance their projects, contributing to the development of new pharmaceutical solutions. For detailed pricing and availability, contacting a specialized chemical supplier is recommended.