For chemists engaged in intricate organic synthesis, the selection of reliable and reactive building blocks is fundamental to success. 2-Bromo-3-methoxypyridine emerges as a compound of significant interest, offering a unique combination of functional groups that unlock diverse synthetic possibilities. This article aims to guide researchers and procurement specialists on its chemical properties, reactivity, and the advantages of sourcing it from expert manufacturers.

Understanding the Chemistry of 2-Bromo-3-methoxypyridine

2-Bromo-3-methoxypyridine (CAS 24100-18-3) is a halogenated pyridine derivative. Its molecular structure is key to its synthetic utility:

  • Pyridine Ring: The aromatic heterocyclic nitrogen ring provides a scaffold that can influence electron distribution and reactivity.
  • Bromine Atom: Located at the 2-position, this is a key leaving group, making the compound susceptible to nucleophilic aromatic substitution and, crucially, participation in palladium-catalyzed cross-coupling reactions. This allows for the facile introduction of carbon-carbon or carbon-heteroatom bonds.
  • Methoxy Group: Positioned at the 3-position, this electron-donating group can activate the pyridine ring towards electrophilic substitution and influence the regioselectivity of reactions. It also impacts the physical properties of molecules derived from it.

These features make 2-Bromo-3-methoxypyridine an excellent substrate for transformations like Suzuki-Miyaura coupling, Heck reactions, and Sonogashira couplings, as well as for reactions involving organometallic reagents. Its well-defined reactivity profile ensures predictable outcomes in multistep syntheses.

Key Applications in Synthesis

The versatility of 2-Bromo-3-methoxypyridine translates into broad applications:

  • Pharmaceutical Intermediates: It is a critical starting material for the synthesis of various drug candidates and APIs, particularly those incorporating modified pyridine structures known for their therapeutic potential.
  • Agrochemicals: Its structure can be modified to produce active ingredients for herbicides, insecticides, and fungicides, enhancing crop protection solutions.
  • Materials Science: Researchers explore its use in synthesizing functional materials, such as advanced polymers or organic electronic components, where specific electronic and structural properties are required.
  • General Organic Synthesis: It serves as a valuable building block for academic and industrial researchers creating complex organic molecules with tailored properties.

Sourcing for Your Synthesis Projects: The Importance of Purity and Supply

When you need to buy 2-Bromo-3-methoxypyridine, prioritizing purity is non-negotiable for successful synthesis. Impurities can lead to unwanted side reactions, lower yields, and complicate purification processes. Manufacturers in China, such as NINGBO INNO PHARMCHEM CO.,LTD., are equipped to produce this intermediate at high purities, often exceeding 99.0% via GC analysis. This guarantees the reliability and reproducibility of your reactions.

As a leading manufacturer and supplier, we provide comprehensive product specifications and safety data, ensuring you have all the necessary information for safe and effective use. For bulk orders or to inquire about pricing, our dedicated team is ready to assist. Securing a consistent and high-quality supply chain for critical intermediates like 2-Bromo-3-methoxypyridine is a strategic advantage for any synthetic chemistry laboratory or manufacturing facility.