For researchers in the pharmaceutical and biotechnology sectors, the journey of peptide synthesis involves navigating a complex array of chemical reagents and intermediates. (Butoxycarbonylamino)cyclohexanecarboxylic Acid (CAS 222530-33-8) is a particularly valuable compound, serving as a key chiral building block in the synthesis of peptides and peptide-based drugs. This article is designed for R&D scientists, providing guidance on the effective use of this intermediate and the importance of sourcing it from reputable manufacturers and suppliers, with a focus on the advantages offered by China-based companies.

The Functional Role of CAS 222530-33-8 in Peptide Synthesis

(Butoxycarbonylamino)cyclohexanecarboxylic Acid, with its molecular formula C12H21NO4, is a non-proteinogenic amino acid derivative characterized by a protected amine group (Boc) and a carboxylic acid. This structure makes it ideal for solid-phase peptide synthesis (SPPS) and solution-phase synthesis. The Boc protection strategy is widely used due to its stability under various reaction conditions and its straightforward removal using acidic treatment, ensuring controlled chain elongation. The cyclohexane ring offers a rigid conformational constraint, which can be crucial for designing peptides with specific biological activities or improved metabolic stability. For scientists aiming to synthesize novel peptides or improve existing ones, obtaining this intermediate with a high purity (typically 99% min) is essential for successful coupling reactions and to avoid unwanted side products. The typical melting point of 143-147℃ serves as a key physical characteristic to verify.

Sourcing High-Purity Intermediates: The Manufacturer's Advantage

When it comes to procuring essential chemical building blocks, partnering with a direct manufacturer offers significant benefits for R&D scientists. A reliable manufacturer in China, such as NINGBO INNO PHARMCHEM CO.,LTD., can provide access to high-purity (Butoxycarbonylamino)cyclohexanecarboxylic Acid at competitive prices. These companies often possess advanced synthesis capabilities and adhere to stringent quality control protocols, ensuring lot-to-lot consistency. For R&D projects, where experimental outcomes depend heavily on the quality of reagents, this consistency is invaluable. Furthermore, the ability to readily buy the compound with available technical support and documentation, such as Certificates of Analysis, streamlines the research process. Requesting a free sample is a standard and recommended practice to validate the intermediate's suitability for your specific peptide synthesis strategy.

Optimizing Peptide Design and Synthesis

Incorporating (Butoxycarbonylamino)cyclohexanecarboxylic Acid into a peptide sequence can introduce unique structural features. For instance, it can mimic proline in certain positions, affecting secondary structure, or serve as a scaffold for introducing side-chain modifications. Researchers may explore its use in creating peptidomimetics or cyclic peptides, which often exhibit enhanced stability and bioavailability compared to their linear counterparts. When planning your synthesis, consult available scientific literature for examples of its application and consider the best coupling reagents and deprotection strategies that complement its use. The availability of this intermediate from trusted suppliers at a reasonable price makes it an accessible tool for cutting-edge peptide research.

Conclusion

For R&D scientists engaged in peptide synthesis, understanding the utility and sourcing of key intermediates like (Butoxycarbonylamino)cyclohexanecarboxylic Acid (CAS 222530-33-8) is vital. Partnering with reputable Chinese manufacturers and suppliers ensures access to high-quality, pure material at competitive prices, facilitating successful research and development. We encourage you to explore the offerings of established chemical providers to support your groundbreaking work in peptide science.