While Disodium EDTA offers significant benefits, particularly in medical applications, it is essential to be aware of its potential risks and side effects. When administered intravenously for therapeutic purposes, such as heavy metal detoxification or certain cardiovascular treatments, EDTA must be used under the strict supervision of qualified healthcare professionals. The most commonly reported side effect is irritation or burning at the IV site. However, more serious adverse effects can occur, including kidney damage, anemia, and significant electrolyte imbalances, such as dangerously low levels of magnesium and potassium, which can lead to severe cardiac arrhythmias.

Interactions with certain medications, such as insulin, warfarin, and diuretics, can also pose risks, potentially leading to amplified side effects or reduced efficacy of either the EDTA or the other medication. Individuals with pre-existing conditions like asthma, diabetes, heart disease, kidney disease, or low electrolyte levels must exercise extreme caution and consult their physician before considering EDTA therapy.

The FDA regulates over-the-counter EDTA supplements, but their safety and efficacy are not as rigorously tested as prescription medications. The variability in supplement quality and the lack of established optimal dosages make their use potentially risky. Therefore, for any therapeutic application of EDTA, consulting with a healthcare provider is paramount to ensure safety, determine appropriate dosages, and monitor for any adverse reactions. Responsible usage is key to harnessing the benefits of Disodium EDTA while mitigating its inherent risks.