Ofloxacin, a widely prescribed synthetic chemotherapeutic antibacterial agent, belongs to the fluoroquinolone class of antibiotics. Its efficacy against a broad spectrum of Gram-positive and Gram-negative bacteria has made it an essential drug in clinical practice. The synthesis of Ofloxacin is a complex organic process involving several key intermediates, each playing a crucial role in building the final molecular structure. For pharmaceutical chemists and manufacturers, a thorough understanding of these intermediates, including their quality requirements and sourcing, is vital for efficient and compliant API production.

The Synthetic Pathway to Ofloxacin

The synthesis of Ofloxacin typically involves a series of chemical transformations. While various routes exist, a common approach utilizes a fluoro-substituted quinoline core that is then elaborated to form the final drug molecule. A critical intermediate in many such synthetic schemes is 1-(2,3-difluoro-6-nitrophenoxy)propan-2-one (CAS: 82419-32-7). This compound provides a fluorinated aromatic moiety and a reactive ketone group, which are strategically utilized in building the complex structure of Ofloxacin. The precise chemical structure and purity of this intermediate directly influence the subsequent reaction steps and the overall quality of the Ofloxacin API.

The Role of 1-(2,3-Difluoro-6-nitrophenoxy)propan-2-one (CAS: 82419-32-7)

1-(2,3-difluoro-6-nitrophenoxy)propan-2-one serves as a precursor that, through a series of reactions including cyclization and functional group modifications, contributes to the core fluorinated bicyclic system of Ofloxacin. The fluorine atoms on the phenyl ring are retained in the final Ofloxacin structure, contributing to its potent antibacterial activity and favorable pharmacokinetic properties. The nitro group often undergoes reduction or displacement in later steps. As a pharmaceutical intermediate manufacturer, our focus is on providing this compound at high purity (≥95% min), ensuring it performs reliably in sensitive synthetic processes. Sourcing this specific intermediate from a reputable supplier is a critical step for any manufacturer aiming for efficient Ofloxacin production.

Sourcing High-Quality Intermediates: A Procurement Perspective

For companies that need to buy 1-(2,3-difluoro-6-nitrophenoxy)propan-2-one, the selection of a supplier is as important as the synthesis route itself. Key considerations for procurement professionals include:

  • Purity and Specifications: Confirm that the intermediate meets the specified purity (≥95% min) and physical characteristics (yellow crystalline powder, MP 40-45 °C).
  • Reliability of Supply: Ensure the manufacturer can consistently deliver the required quantities, offering stability to your production schedule.
  • Documentation: Access to a comprehensive Certificate of Analysis (CoA) and Safety Data Sheet (SDS) is mandatory for quality control and regulatory compliance.
  • Competitive Pricing: Partnering with a cost-effective manufacturer, especially one in China known for its chemical production capabilities, can significantly reduce overall API costs.

We, as a dedicated chemical supplier, specialize in providing intermediates like 1-(2,3-difluoro-6-nitrophenoxy)propan-2-one, meeting the stringent requirements of the pharmaceutical industry. Our commitment to quality and efficient production ensures that your Ofloxacin synthesis projects can proceed smoothly and cost-effectively.

In summary, the synthesis of Ofloxacin is a testament to the power of organic chemistry, relying on precisely engineered intermediates to achieve the final drug's therapeutic profile. Understanding the role of compounds like 1-(2,3-difluoro-6-nitrophenoxy)propan-2-one (CAS: 82419-32-7) and sourcing them from trusted manufacturers is fundamental to successful API manufacturing.