The synthesis of heterocyclic compounds, particularly those containing nitrogen and oxygen, is a cornerstone of modern organic chemistry, with significant implications for drug discovery and materials science. Among these, oxadiazole derivatives stand out due to their versatile biological activities and chemical properties. For researchers engaged in synthesizing novel oxadiazoles, having access to high-quality intermediates is paramount. This article focuses on a key intermediate, CAS 147085-13-0, and guides chemists on sourcing and utilizing it effectively.

The Chemistry of Oxadiazoles and CAS 147085-13-0

Oxadiazoles are five-membered aromatic rings containing one oxygen atom and two nitrogen atoms. Their arrangement dictates distinct isomeric forms (1,2,3-, 1,2,4-, 1,2,5-, and 1,3,4-oxadiazoles), each offering unique chemical behavior and potential applications. CAS 147085-13-0, 4-Amino-N-hydroxy-1,2,5-oxadiazole-3-carboximidoyl Chloride, belongs to the 1,2,5-oxadiazole (furazan) family and possesses reactive functional groups – an amino group and a carboximidoyl chloride – that make it an excellent precursor for further functionalization. The ability to precisely control the synthesis of such complex structures is often dependent on the purity of the starting materials, underscoring the importance of sourcing high-quality intermediates.

Challenges and Solutions in Oxadiazole Synthesis

Synthesizing oxadiazoles can sometimes present challenges, including regioselectivity issues, the need for specific reaction conditions, and the handling of potentially sensitive intermediates. The carboximidoyl chloride group in CAS 147085-13-0, for instance, is highly reactive and may require controlled reaction environments to prevent degradation or unwanted side reactions. Researchers often consult scientific literature and product documentation from chemical intermediate manufacturers to understand optimal reaction pathways and handling protocols. Access to detailed product specifications, such as boiling point, density, and recommended storage temperatures (2-8°C for CAS 147085-13-0), is crucial for successful laboratory work.

Sourcing High-Purity Intermediates

For chemists looking to buy compounds like CAS 147085-13-0, identifying reliable suppliers is key. A reputable specialty chemical supplier will guarantee product purity (e.g., 97% min) and provide comprehensive technical support. Many global suppliers, particularly those based in China, offer a wide range of heterocyclic intermediates. It is advisable to compare pricing, product availability, and shipping options when requesting a quotation. Many companies specialize in custom synthesis, which can be a valuable resource if specific modifications or larger quantities of an intermediate are required.

Applications and Future Prospects

The versatility of oxadiazole derivatives makes them prime candidates for various applications, including pharmaceuticals, agrochemicals, and materials science. The specific structural features of CAS 147085-13-0 suggest its utility in constructing libraries of novel compounds for high-throughput screening or in the development of targeted therapeutic agents. As research into new materials and medicines continues, the demand for such well-defined building blocks will undoubtedly grow, making it important to know where to purchase them reliably.

Conclusion

Navigating the synthesis of oxadiazole derivatives requires a careful selection of intermediates and a strategic approach to sourcing. 4-Amino-N-hydroxy-1,2,5-oxadiazole-3-carboximidoyl Chloride (CAS: 147085-13-0) is a prime example of a valuable intermediate. By understanding its properties and identifying trusted suppliers of high-purity chemical intermediates, chemists can accelerate their research and development efforts.