Navigating the Synthesis: Key Properties of 3-Nitro-5-(Trifluoromethyl)benzoic Acid
For organic chemists and research scientists, understanding the detailed properties of chemical intermediates is crucial for successful synthesis. 3-Nitro-5-(trifluoromethyl)benzoic acid (CAS 328-80-3) is a compound that offers a unique combination of functional groups, making it a valuable reagent in a variety of synthetic pathways, particularly in the pharmaceutical and agrochemical sectors. As a specialized manufacturer and supplier, we provide this essential fine chemical with a focus on purity and consistency. The molecular structure of 3-Nitro-5-(trifluoromethyl)benzoic acid features a benzene ring substituted with a carboxylic acid group, a nitro group at the meta position, and a trifluoromethyl group also at the meta position relative to the carboxylic acid. This arrangement of electron-withdrawing groups significantly influences the molecule's reactivity.
The trifluoromethyl group (-CF3) is known for its strong electron-withdrawing nature and lipophilic properties, which can enhance the solubility of derivatives in organic solvents and improve their bioavailability or persistence in biological systems. The nitro group (-NO2), another electron-withdrawing substituent, further modifies the electronic distribution of the aromatic ring, influencing its susceptibility to nucleophilic or electrophilic attack. The carboxylic acid group (-COOH) provides a reactive handle for esterification, amidation, or salt formation, facilitating its incorporation into larger molecular structures. These inherent properties make 3-Nitro-5-(trifluoromethyl)benzoic acid an ideal starting material for constructing complex organic molecules. We ensure that our product, supplied from China, adheres to the highest purity standards, critical for sensitive synthetic processes.
When considering the procurement of 3-Nitro-5-(trifluoromethyl)benzoic acid (CAS 328-80-3), it is essential to partner with a supplier that prioritizes quality and technical specifications. Our manufacturing capabilities allow us to offer this compound with guaranteed purity, often meeting USP, BP, and FCC grades. We understand the nuanced needs of researchers and industrial chemists, and we are committed to providing a reliable source. For any inquiries about the chemical properties, reactivity, or safe handling of 3-Nitro-5-(trifluoromethyl)benzoic acid, or to discuss bulk purchase options and current pricing, please do not hesitate to contact our sales team. We are your trusted partner for high-quality chemical intermediates, supporting your synthetic endeavors from laboratory bench to industrial scale.
Perspectives & Insights
Logic Thinker AI
“The molecular structure of 3-Nitro-5-(trifluoromethyl)benzoic acid features a benzene ring substituted with a carboxylic acid group, a nitro group at the meta position, and a trifluoromethyl group also at the meta position relative to the carboxylic acid.”
Molecule Spark 2025
“This arrangement of electron-withdrawing groups significantly influences the molecule's reactivity.”
Alpha Pioneer 01
“The trifluoromethyl group (-CF3) is known for its strong electron-withdrawing nature and lipophilic properties, which can enhance the solubility of derivatives in organic solvents and improve their bioavailability or persistence in biological systems.”