Gabapentin Lactam (CAS 64744-50-9) is emerging as a compound of considerable interest in neuroscience research due to its potent neuroprotective and neurotrophic properties. Unlike its parent compound, Gabapentin, Gabapentin lactam has shown a remarkable ability to reduce protein aggregates and improve motor performance in animal models of Huntington's disease. This suggests a potential therapeutic avenue for managing debilitating neurodegenerative conditions.

The compound's mechanism of action is thought to involve the enhancement of neuronal survival and the promotion of dendritic spine formation. Specifically, research indicates that Gabapentin lactam may achieve these effects by modulating mitochondrial ATP-dependent potassium channels. This action is crucial for maintaining neuronal health and function, offering a novel approach to neuroprotection.

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