The pharmaceutical industry constantly strives for efficiency and quality in drug manufacturing. For Apixaban, a widely prescribed anticoagulant, the synthesis pathway involves several crucial intermediates, with 1-(4-Nitrophenyl)piperidin-2-one (CAS: 38560-30-4) standing out as a cornerstone. Understanding the properties and sourcing of this intermediate is vital for any manufacturer aiming for cost-effective and high-quality Apixaban production.

The Chemical Backbone: 1-(4-Nitrophenyl)piperidin-2-one

1-(4-Nitrophenyl)piperidin-2-one is a chemical compound that provides the essential structural framework required for building the complex molecule of Apixaban. Its synthesis, often performed by specialized chemical manufacturers, involves precise chemical reactions to ensure high purity, typically exceeding 98%. This purity is non-negotiable, as impurities in intermediates can lead to challenges in downstream processing, affect the final API's quality, and complicate regulatory submissions.

When pharmaceutical companies look to buy 1-(4-Nitrophenyl)piperidin-2-one, they are seeking a reliable product that minimizes batch-to-batch variability. As a dedicated manufacturer of 1-(4-Nitrophenyl)piperidin-2-one, our focus is on delivering precisely that: a consistent, high-purity intermediate that streamlines your Apixaban production.

Synthesis and Quality Control from a Chemical Manufacturer's Perspective

The manufacturing of 1-(4-Nitrophenyl)piperidin-2-one is typically achieved through advanced organic synthesis techniques. The SNAr reaction pathway, utilizing reagents like 1-fluoro-4-nitrobenzene and sodium amide, is a common and efficient method. However, optimization of reaction conditions such as temperature, solvent choice (e.g., DMF, DMSO), and base catalysis is crucial. Manufacturers invest in robust process controls to manage exotherms, prevent side reactions, and ensure the purity of the final product. For instance, maintaining temperatures between 80-90°C balances reaction kinetics with product stability, leading to yields of 70-85% with purities often above 95%.

We pride ourselves on our rigorous quality control procedures. Every batch of 1-(4-Nitrophenyl)piperidin-2-one undergoes thorough analysis to confirm its identity, purity (assay ≥98.0%), and physical properties. This commitment means that when you purchase 1-(4-Nitrophenyl)piperidin-2-one from us, you receive a product that meets stringent pharmaceutical standards, supporting your Quality Assurance (QA) and Quality Control (QC) requirements.

Sourcing Strategies: Price, Availability, and Reliability

The price of 1-(4-Nitrophenyl)piperidin-2-one can vary based on manufacturing complexity, scale, and supplier. However, by partnering with an established chemical supplier, particularly one with significant production capacity in regions like China, you can achieve better cost-effectiveness. Availability is another key consideration; ensuring a steady supply chain for intermediates is critical to avoid production delays. We, as a dedicated supplier of 1-(4-Nitrophenyl)piperidin-2-one, focus on maintaining strong inventory levels and efficient logistics to guarantee timely delivery.

We encourage all pharmaceutical companies to inquire about our product specifications and to request a quote for their required quantities. Understanding the CAS 38560-30-4 for accurate sourcing is essential. Let us be your trusted partner for this vital pharmaceutical intermediate.

In summary, the successful and efficient manufacturing of Apixaban hinges on the quality and reliable supply of its key intermediates like 1-(4-Nitrophenyl)piperidin-2-one. By choosing a manufacturer committed to synthesis optimization and stringent quality control, pharmaceutical companies can ensure the integrity of their final product and maintain a competitive edge. We invite you to buy 1-(4-Nitrophenyl)piperidin-2-one from a manufacturer dedicated to excellence.