The efficacy and safety of pharmaceutical products hinge significantly on the quality of their constituent intermediates. For the synthesis of darifenacin, a crucial active pharmaceutical ingredient (API), the intermediate 2,3-Dichlorobenzotrifluoride (CAS 54773-19-2) plays a pivotal role. This article delves into why sourcing high-quality 2,3-Dichlorobenzotrifluoride is critical for optimizing darifenacin production and how R&D scientists and procurement specialists can ensure they buy from the best possible suppliers.

The Importance of 2,3-Dichlorobenzotrifluoride in Darifenacin Synthesis

2,3-Dichlorobenzotrifluoride is a key building block in the multi-step synthesis of darifenacin. Its specific structural features, including the trifluoromethyl group and chlorine substituents on the benzene ring, are integral to forming the final drug molecule's therapeutic properties. Impurities or variations in the quality of this intermediate can lead to:

  • Reduced reaction yields
  • Formation of unwanted by-products
  • Increased purification costs
  • Potential impact on the final API's safety and efficacy profile

Therefore, when companies look to purchase 2,3-Dichlorobenzotrifluoride, they are not just buying a chemical; they are investing in the integrity of their downstream manufacturing process.

Key Quality Parameters to Verify

For procurement professionals and formulation chemists, verifying the quality of 2,3-Dichlorobenzotrifluoride (CAS 54773-19-2) is a non-negotiable step. Critical parameters to check include:

  • Chemical Purity: Typically specified by HPLC, ensuring minimal impurities.
  • Physical State: Confirmation that it is supplied as a clear, colorless liquid, as expected.
  • CAS Number Accuracy: Double-checking CAS 54773-19-2 to ensure the correct isomer is sourced.
  • Supplier Certification: Availability of Certificates of Analysis (CoA) and adherence to Good Manufacturing Practices (GMP) where applicable.

Choosing Your Supplier for 2,3-Dichlorobenzotrifluoride

Identifying a reliable manufacturer for pharmaceutical intermediates requires due diligence. Look for companies that:

  • Demonstrate robust quality control systems.
  • Offer consistent batch-to-batch quality.
  • Provide transparent technical support and responsive customer service.
  • Have a strong supply chain, ensuring availability and competitive pricing.
  • Are experienced in exporting chemicals, particularly to your region.

As a dedicated manufacturer and supplier of fine chemicals, we understand the stringent demands of the pharmaceutical industry. We are committed to providing high-purity 2,3-Dichlorobenzotrifluoride that supports efficient and reliable darifenacin synthesis. If you are looking to buy this critical intermediate, we invite you to explore our offerings and benefit from our expertise and competitive price points. Secure your supply chain and optimize your synthesis process by partnering with a trusted chemical provider.