For professionals involved in the pharmaceutical synthesis of Eluxadoline, a leading medication for Irritable Bowel Syndrome with Diarrhea (IBS-D), securing a reliable supply of the key intermediate, (S)-1-(4-Phenyl-1H-imidazol-2-yl)ethanamine (CAS 864825-23-0), is crucial. This chiral molecule is fundamental to the efficacy and safety of the final API. This article outlines key strategies for procurement managers and R&D scientists to optimize their sourcing for this vital compound.

Understanding the Intermediate's Significance

The therapeutic action of Eluxadoline is linked to its specific molecular structure, which is built upon the precise stereochemistry of (S)-1-(4-Phenyl-1H-imidazol-2-yl)ethanamine. This means that any deviation in purity or chirality can significantly impact the drug's performance. Therefore, when searching for an Eluxadoline intermediate manufacturer, the emphasis must be on suppliers who can guarantee high enantiomeric purity (often specified as ≥99.0% assay) and consistent batch-to-batch quality. R&D teams often require detailed technical specifications and analytical data to confirm the intermediate's suitability for their specific synthetic routes.

Identifying Reputable Suppliers in China

China has emerged as a global hub for fine chemical and pharmaceutical intermediate manufacturing. For companies looking to buy (S)-1-(4-Phenyl-1H-imidazol-2-yl)ethanamine, identifying a reputable Chinese manufacturer can provide both quality and cost advantages. Key selection criteria include:

  • Quality Control Systems: Verify that the supplier has robust quality management systems in place, adhering to international standards. Look for evidence of advanced analytical capabilities.
  • Production Capacity and Reliability: Ensure the manufacturer can meet your projected volume requirements and has a history of consistent delivery.
  • Regulatory Compliance: While intermediates are not always subject to the same regulations as APIs, a supplier aware of and compliant with relevant chemical industry regulations is preferable.
  • Technical Support: A supplier offering technical assistance and clear communication channels can greatly streamline the procurement process.

Companies specializing in custom synthesis or offering a broad catalog of pharmaceutical intermediates are often good starting points. Many prominent suppliers in China can offer competitive CAS 864825-23-0 prices for bulk orders.

Procurement Best Practices

When initiating the procurement process, it is advisable to:

  • Request Detailed Quotes: Obtain comprehensive quotes that include pricing per unit, pack sizes, lead times, and shipping costs.
  • Secure Samples: Always request samples for internal validation before committing to large orders. This allows your R&D team to test the intermediate in your specific process.
  • Establish Clear Payment Terms: Discuss and agree upon payment terms upfront to ensure a smooth transaction.
  • Plan for Lead Times: Factor in potential lead times for both production and international shipping, especially for critical drug development timelines.

By implementing these sourcing strategies, pharmaceutical companies can ensure a consistent and high-quality supply of (S)-1-(4-Phenyl-1H-imidazol-2-yl)ethanamine, thereby optimizing their Eluxadoline synthesis and accelerating the journey from laboratory to market. Partnering with a trusted pharmaceutical intermediate supplier is key to achieving these goals.