For organic chemists and researchers, the selection of appropriate reagents and intermediates is fundamental to the success of synthetic endeavors. 3'-Chloroacetophenone, with its CAS number 99-02-5, represents a versatile and valuable building block in the realm of organic synthesis. This aromatic ketone, characterized by a chlorine atom positioned meta to the acetyl group, offers unique reactivity that can be leveraged in a multitude of chemical transformations. Its utility spans from the creation of complex pharmaceutical molecules to the development of novel fine chemicals.

Chemical Properties and Reactivity of 3'-Chloroacetophenone

As a chemical intermediate, 3'-Chloroacetophenone typically presents as a clear to light yellow liquid. Its molecular formula, C8H7ClO, and molecular weight of approximately 154.59 g/mol provide the basic framework for its applications. The presence of the carbonyl group makes it susceptible to nucleophilic addition reactions, while the aromatic ring can undergo electrophilic aromatic substitution. The meta-positioned chlorine atom influences the electron density of the ring and can also be a site for further functionalization, such as in cross-coupling reactions, depending on the reaction conditions and catalyst used. Chemists often select 3'-Chloroacetophenone when aiming to introduce a specific chlorinated phenyl ketone moiety into a larger molecular structure.

Applications in Research and Development

In research laboratories, 3'-Chloroacetophenone is frequently employed as a starting material or intermediate for synthesizing a diverse array of organic compounds. Its known applications include:

  • Pharmaceuticals: As mentioned previously, it's a key precursor for certain epilepsy medications. It can also be a stepping stone for other therapeutic agents.
  • Fine Chemicals: Used in the synthesis of specialty chemicals that may find applications in materials science, dyes, or fragrances.
  • Agrochemicals: Its structure lends itself to being an intermediate in the production of pesticides and other crop protection agents.
  • Methodology Development: Chemists may use it to test new synthetic methodologies or catalytic systems due to its well-defined reactivity.

When looking to buy 3'-chloroacetophenone for research, purity is a critical factor. Researchers often require materials with purity levels of 99% or higher to ensure predictable reaction outcomes and to minimize the generation of unwanted byproducts. Understanding the typical 3'-chloroacetophenone price associated with different quantities is also important for budget planning in academic and industrial research.

Sourcing Strategies for Chemists

For chemists requiring 3'-Chloroacetophenone, reliable sourcing is essential. Partnering with established chemical suppliers and manufacturers, particularly those with a strong presence in producing pharmaceutical intermediates, is advisable. Companies that provide detailed technical specifications, such as appearance, assay, and CAS number, along with readily available Safety Data Sheets (SDS) and Certificates of Analysis (CoA), facilitate efficient procurement and safe handling. Availability from manufacturers in China, known for their capacity to produce these intermediates at scale and competitive pricing, is a common sourcing route.

In essence, 3'-Chloroacetophenone remains a valuable tool in the organic chemist's arsenal, enabling the construction of complex molecules with diverse applications. A strategic approach to sourcing ensures that researchers have access to this crucial intermediate, fostering innovation in chemical synthesis.