The field of peptide therapeutics and research is experiencing rapid growth, with amino acid derivatives playing a pivotal role. Among these, N-(tert-Butoxycarbonyl)-L-phenylalanine, or Boc-L-Phenylalanine (CAS 13734-34-4), is a cornerstone reagent for efficient and controlled peptide synthesis. For R&D scientists and procurement specialists, understanding its application and how to secure a dependable supply is key to accelerating discovery and production.

The Role of Boc Protection in Peptide Synthesis

Peptide synthesis involves the sequential coupling of amino acids. To ensure that the correct linkages are formed and to prevent unwanted side reactions, amino groups of amino acids are temporarily protected. The tert-butyloxycarbonyl (Boc) group is one of the most widely used protecting groups in peptide chemistry. It is stable under various coupling conditions but can be readily removed under mild acidic conditions (e.g., using trifluoroacetic acid), regenerating the free amine for the next coupling step. Boc-L-Phenylalanine, with its phenyl side chain and Boc-protected alpha-amino group, is a versatile component for incorporating phenylalanine residues into peptide sequences.

Why Choose Boc-L-Phenylalanine?

When building peptides, the choice of protected amino acids impacts efficiency, yield, and the purity of the final product. Boc-L-Phenylalanine offers several advantages:

  • Selective Deprotection: The Boc group's lability to acid allows for orthogonal protection strategies, where other protecting groups (like Fmoc) are removed by different conditions.
  • Good Solubility: It exhibits good solubility in common organic solvents used in peptide synthesis, facilitating reaction and purification processes.
  • Versatile Building Block: L-Phenylalanine is a common amino acid in biologically active peptides, making its Boc-protected form a frequently used reagent.

Finding a Reliable Boc-L-Phenylalanine Supplier

Securing a consistent supply of Boc-L-Phenylalanine with the required purity is critical for successful peptide synthesis projects. When looking to buy Boc-L-Phenylalanine, consider the following:

  • Purity and Specifications: Always request a detailed Certificate of Analysis (CoA) that confirms purity levels (e.g., >99.0% HPLC), enantiomeric purity, and absence of critical impurities.
  • Manufacturer Reputation: Partner with established manufacturers or authorized suppliers known for quality control and consistent production. Sourcing from a reputable manufacturer in China can offer competitive price points and high-volume capacity.
  • Quantity and Lead Time: Ensure the supplier can meet your current and future volume requirements, whether for R&D scale or commercial production, and confirm their delivery timelines.
  • Regulatory Compliance: For pharmaceutical or clinical applications, verify that the supplier adheres to relevant quality standards and can provide necessary documentation.

For researchers and chemical purchasers, identifying a dependable supplier for Boc-L-Phenylalanine (CAS 13734-34-4) means less time spent on quality control issues and more time focused on the scientific and development aspects of peptide synthesis. A supplier's ability to offer competitive pricing and technical support further enhances the value proposition.

In summary, Boc-L-Phenylalanine is an essential component for modern peptide synthesis. By prioritizing quality and working with trusted sources, researchers and manufacturers can leverage its properties to create complex peptide molecules efficiently and effectively.