In the pursuit of novel therapeutic peptides and advanced biomaterials, chemists are constantly seeking ways to modify peptide structures for improved stability, bioavailability, and targeted activity. Incorporating non-natural amino acids with specific side-chain modifications is a key strategy. NINGBO INNO PHARMCHEM CO.,LTD., a leading supplier of specialized amino acid derivatives, offers Fmoc-(S)-3-Amino-4-(3,4-dichlorophenyl)butyric Acid, a valuable tool for optimizing peptide synthesis. This article explores the benefits of using this unique building block in your research.

Fmoc-(S)-3-Amino-4-(3,4-dichlorophenyl)butyric Acid (CAS: 270063-52-0) stands out due to its dichlorinated phenyl ring on the side chain. The presence of chlorine atoms can significantly influence the physical and chemical properties of a peptide. For instance, the electronegativity of chlorine can alter the electronic environment of the peptide backbone, potentially affecting its conformation, receptor binding affinity, or resistance to enzymatic degradation. Researchers often buy such modified amino acids to increase the lipophilicity of peptides, which can improve cell membrane permeability and oral bioavailability—key challenges in peptide drug development. The Fmoc group ensures its compatibility with standard SPPS protocols.

The strategic incorporation of the 3,4-dichlorophenyl moiety can also enhance the stability of peptides against proteases. The bulky and electron-withdrawing nature of the dichloro-substituted ring can sterically hinder enzymatic cleavage sites or alter the local environment, making the peptide more resistant to degradation in biological fluids. This increased stability is crucial for peptides intended for therapeutic use, as it can prolong their half-life in the body. As a dedicated manufacturer, NINGBO INNO PHARMCHEM CO.,LTD. provides this advanced amino acid derivative with a high purity of 97%, ensuring that these desired properties are introduced into your synthesized peptides without interference from impurities.

For peptide chemists and scientists, sourcing reliable building blocks is essential for successful synthesis. NINGBO INNO PHARMCHEM CO.,LTD. serves as a premier supplier from China, offering this and other specialized amino acids at competitive prices. Our commitment to quality and consistent supply empowers researchers to push the boundaries of peptide science. We encourage you to consider Fmoc-(S)-3-Amino-4-(3,4-dichlorophenyl)butyric Acid for your next peptide synthesis project and to connect with us for detailed product information, pricing, and to place your order.